Related Experiment Video
Updated: May 27, 2025

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
Published on: June 24, 2020
Pregnancy-onset inflammatory bowel disease: A case report.
Maya Deeb1,2, Parul Tandon1,2, Vivian Huang1,2
1Department of Medicine, University of Toronto, Toronto, ON, Canada.
Pregnancy-onset inflammatory bowel disease (POIBD) requires high clinical suspicion due to delayed diagnosis risks. Prompt management is crucial to prevent severe maternal and neonatal complications, improving outcomes for both.
Area of Science:
- Gastroenterology
- Obstetrics
- Internal Medicine
Background:
- Pregnancy-onset inflammatory bowel disease (POIBD) is rare, with limited data on its clinical course and outcomes.
- POIBD is associated with diagnostic delays and higher hospitalization rates compared to non-pregnant patients.
Purpose of the Study:
- To highlight the challenges in diagnosing and managing POIBD.
- To underscore the importance of timely intervention for maternal and fetal well-being.
Main Methods:
- Case report of a 29-year-old pregnant patient with acute severe ulcerative colitis.
- Review of clinical presentation, diagnostic delays, complications, and outcomes.
Main Results:
- The patient experienced delayed diagnosis and therapy, leading to colonic perforation and colectomy.
- Complications included prolonged hospitalization and neonatal prematurity.
- This case emphasizes the need for a high index of suspicion for POIBD.
Conclusions:
- Early diagnosis and prompt inpatient management are critical for preventing severe maternal and neonatal morbidity in POIBD.
- Advocacy for timely investigations in pregnant patients with gastrointestinal symptoms is essential.
Related Concept Videos
Inflammatory Bowel Disease II: Crohn's Disease
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Inflammatory Bowel Disease I: Ulcerative Colitis
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Chronic Bowel Disorders: Introduction
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome I: Introduction
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids

