Fish eye-lens reagents: a possible new class of reagents for molecular and cellular identification

Initial studies have shown that fish lens protein can be modified in vitro to acquire a specific affinity for selected molecules, e.g., human hemoglobins, and cells, e.g., human erythrocytes. These studies were extended by preparing lens reagents that can distinguish bovine serum albumin from ovalbumin, and major groups of human erythrocytes in the ABO system from each other. Lens reagents appear to be potentially useful tools for the identification of specific molecules, either in solution or on cell surfaces.