Epicutaneous induction of tolerance with acrylates and related compounds

Epicutaneous application of acrylates and related compounds 14 and 7 days before sensitization with either methyl acrylate or trimethylol propane triacrylate induced tolerance to the resultant contact reactions. This tolerance could not be correlated with either the degree of cross reactivity between these compounds or with their ability to react covalently with amino or sulphydryl groups of proteins. These results are discussed in relation to other epicutaneous tolerizers in the dinitrobenzene and poison ivy systems.