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Advances and insights for DKK3 in non-cancerous diseases: a systematic review
Yao Sun1, Zengli Xiao1, Shuguang Yang1
1Intensive Care Unit, Peking University People's Hospital, Beijing, China.
Abstract:
This review delves into the role of Dickkopf-3 (DKK3), a secreted glycoprotein and member of the Dickkopf family, in non-malignant diseases. DKK3 is particularly known for its regulatory effects on the Wnt signaling pathway, a critical mediator in various biological processes including cell proliferation, differentiation, and migration. Our review highlights DKK3's influence in disorders of the cardiovascular, respiratory, renal, and muscular systems, where it contributes to disease progression by modulating these key biological processes. As an emerging biomarker, DKK3's levels have been found to correlate with various disease states, underscoring its potential diagnostic and therapeutic implications.
Insights
Dickkopf-3 (DKK3) influences non-malignant diseases by regulating Wnt signaling. DKK3 shows potential as a biomarker for cardiovascular, respiratory, renal, and muscular system disorders.
Area of Science:
- Biochemistry
- Molecular Biology
- Pathology
Background:
- Dickkopf-3 (DKK3) is a secreted glycoprotein.
- DKK3 is a member of the Dickkopf protein family.
- DKK3 modulates the Wnt signaling pathway, crucial for cell functions.
Purpose of the Study:
- To review the role of DKK3 in non-malignant diseases.
- To explore DKK3's impact on cardiovascular, respiratory, renal, and muscular systems.
- To assess DKK3's potential as a diagnostic and therapeutic biomarker.
Main Methods:
- Literature review of studies on DKK3.
- Analysis of DKK3's involvement in Wnt signaling.
- Examination of DKK3 levels in various disease states.
Main Results:
- DKK3 significantly influences cell proliferation, differentiation, and migration.
- DKK3 plays a role in the progression of cardiovascular, respiratory, renal, and muscular disorders.
- DKK3 levels correlate with disease states, indicating its biomarker potential.
Conclusions:
- DKK3 is a key regulator in non-malignant diseases.
- DKK3 has significant implications for diagnosing and treating various systemic disorders.
- Further research into DKK3's therapeutic potential is warranted.
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