Nanofiber-shaped Co₃O₄@In₂O₃ composite for high-performance enzymeless glucose sensing

Area of Science:

• Electrochemistry
• Materials Science
• Nanotechnology

Background:

• Cobalt tetraoxide (Co3O4) shows promise for enzymeless glucose detection due to redox properties.
• Poor electrical conductivity of Co3O4 limits its catalytic activity in electrochemical sensors.
• Developing enhanced electrode materials is crucial for sensitive glucose monitoring.

Purpose of the Study:

• To develop a novel Co3O4@In2O3 nanofibers (NFs) based electrochemical sensor.
• To improve the conductivity and catalytic activity of Co3O4 for enhanced glucose detection.
• To evaluate the sensor's performance, including limit of detection, sensitivity, selectivity, and stability.

Main Methods:

• Fabrication of Co3O4@In2O3 NFs through a described process.
• Electrochemical characterization of the sensor for glucose detection.
• Evaluation of sensor performance metrics: limit of detection (LoD), detection range, sensitivity, selectivity, reproducibility, and stability.

Main Results:

• The Co3O4@In2O3 NFs sensor achieved an ultra-low LoD of 8.85 nM.
• A wide detection range from 10 nM to 118 μM with high sensitivity (1197.5 μA mM⁻¹ cm⁻²) was demonstrated.
• The sensor exhibited excellent selectivity, reproducibility, and stability over 30 days.

Conclusions:

• The synergistic effect between Co3O4 NFs and In2O3 significantly enhanced glucose sensing performance.
• The developed Co3O4@In2O3 NFs composite offers a promising platform for practical enzymeless glucose analysis.
• This novel material holds potential for development in clinical settings for glucose monitoring.