The Evolution of Multidisciplinary Head and Neck Cancer Treatment

Area of Science:

• Oncology
• Head and Neck Surgery
• Cancer Treatment

Background:

• Head and neck squamous cell carcinoma (HNSCC) management has undergone significant transformation over two centuries.
• Historically, treatment options were limited, but advancements have broadened the therapeutic landscape.

Purpose of the Study:

• To review the historical progression of HNSCC management.
• To focus on the evolution of the multidisciplinary treatment paradigm for HNSCC.

Main Methods:

• A comprehensive historical review synthesizing data from diverse sources.
• Inclusion of historical and current clinical trials, scientific reports, and public documents relevant to HNSCC.

Main Results:

• Treatment evolved from solely surgery to include radiation, chemotherapy, and immunotherapy.
• Modern HNSCC management is characterized by a multidisciplinary and personalized approach.
• Immunotherapy shows promise for recurrent/metastatic HNSCC, with ongoing research into its role in curative settings.

Conclusions:

• Surgery and radiotherapy continue to reduce HNSCC morbidity.
• Platinum-based chemotherapy remains a cornerstone, with increasing use of immunotherapy and targeted therapy.
• Multidisciplinary care and individualized treatment plans are crucial for comprehensive HNSCC management, necessitating further clinical trials.