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Thermally adaptive iohexol-loaded microcages for local computerized tomography.

Jie Qiao^1,2, Jiao Dong^1,2, Jianhao Wang³

¹Guangdong Provincial Key Laboratory of Optical Information Materials and Technology & Institute of Electronic Paper Displays, South China Academy of Advanced Optoelectronics, South China Normal University, Guangzhou, 510006, P. R. China. haoli@m.scnu.edu.cn.

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Summary

Novel thermo-responsive microcages offer targeted X-ray computed tomography (CT) imaging. These smart microcages (MCs) improve contrast agent properties, enhancing safety and efficacy for CT applications.

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Area of Science:

Biomaterials Science
Nanotechnology
Medical Imaging

Background:

X-ray computed tomography (CT) is a widely used non-invasive imaging technique.
Current CT contrast agents have limitations including short in vivo retention, non-specific distribution, and potential nephrotoxicity.
There is a need for improved CT contrast agents with enhanced targeting and safety profiles.

Purpose of the Study:

To develop novel thermo-responsive microcages (MCs) for targeted CT imaging.
To address the limitations of existing CT contrast agents.
To create a safe, effective, and targeted CT contrast agent.

Main Methods:

Synthesized non-ionic poly(acrylamide-co-acrylonitrile) copolymer microcages with an upper critical solution temperature (UCST) between 35-40 °C.
Characterized MCs for hydrodynamic size (5-10 μm), thermo-responsive behavior, and iohexol loading (14.3%) and encapsulation efficiency (16.6%).
Evaluated MCs for heat-enhanced release, biocompatibility, and biosecurity.

Main Results:

Developed thermo-responsive MCs with a suitable UCST for targeted applications.
Demonstrated reversible phase transition for expansion (embolization) and recovery (elimination).
Achieved high iohexol loading and encapsulation, with enhanced release and good biocompatibility.

Conclusions:

The novel thermo-responsive MCs show promise as advanced CT contrast agents.
These smart MCs offer targeted delivery, improved retention, and enhanced safety.
The developed microcages are suitable for facile, effective, and safe CT imaging applications.