Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Recalled experiences of death: need for empirical research without prejudice.

Nature reviews. Neurology·2026
Same author

Analytical model of large-diameter spherical-like catheter for pulsed field ablation in treating cardiac arrhythmias.

Physics in medicine and biology·2025
Same author

Impact of Intrapericardial Fluid on Lesion Size During Epicardial Radiofrequency Ablation: A Computational Study.

Journal of cardiovascular development and disease·2025
Same author

Computer modelling and vegetable bench test of a bipolar electrode array intended for use in high frequency irreversible electroporation treatment of skin cancer.

Biomedical engineering letters·2025
Same author

Proactive esophageal cooling during radiofrequency cardiac ablation: data update including applications in very high-power short duration ablation.

Expert review of medical devices·2024
Same author

Hybrid convergent procedure with proactive oesophageal cooling for the treatment of long-standing persistent atrial fibrillation: a case series.

European heart journal. Case reports·2024
Same journal

Catheter ablation of atrial fibrillation in transthyretin and light-chain cardiac amyloidosis: results from the multicentre AMYL-AF study.

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology·2026
Same journal

Male predominance in sports sudden cardiac arrest: a behavioural driver of risk?

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology·2026
Same journal

Early catheter ablation vs. antiarrhythmic drugs in treatment-naïve ischaemic ventricular tachyarrhythmias: a meta-analysis of randomized controlled trials.

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology·2026
Same journal

Interrater agreement in atrial fibrillation diagnosis using one-week single-lead patch ECG monitoring: Findings from the NORSCREEN trial.

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology·2026
Same journal

Interactions of blood biomolecules with early rhythm control in atrial fibrillation patients: Exploratory analysis of the EAST-AFNET 4 Biomolecule Study.

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology·2026
Same journal

Comment on "Catheter ablation vs. anti-arrhythmic drug therapy for ventricular tachycardia in ischaemic heart disease".

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology·2026
See all related articles

Related Experiment Video

Updated: May 27, 2025

Author Spotlight: Computing the Effects of a Local Radiofrequency Hyperthermia Intervention on Tumor Biomechanics
10:23

Author Spotlight: Computing the Effects of a Local Radiofrequency Hyperthermia Intervention on Tumor Biomechanics

Published on: December 1, 2023

349

Thermal side effects during pulsed field ablation: an analysis using computer modelling.

Marcela Mercado-Montoya1, Tatiana Gomez-Bustamante1, Steven R Mickelsen2

  • 1Bioengineering Department, IN SILICO STEM S.A.S, Calle 52 81-48, Medellín 050035, Colombia.

Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology
|February 17, 2025
PubMed
Summary
This summary is machine-generated.

Pulsed field ablation (PFA) can cause thermal effects, particularly at higher voltages. This study shows peak voltage significantly impacts energy deposition and potential tissue injury during PFA procedures.

Keywords:
In silico modellingAtrial fibrillationComputational analysisPulsed field energySimulationThermal ablation

More Related Videos

Thermal Ablation for the Treatment of Abdominal Tumors
07:16

Thermal Ablation for the Treatment of Abdominal Tumors

Published on: March 7, 2011

34.3K
Emission Spectroscopic Boundary Layer Investigation during Ablative Material Testing in Plasmatron
09:41

Emission Spectroscopic Boundary Layer Investigation during Ablative Material Testing in Plasmatron

Published on: June 9, 2016

12.3K

Related Experiment Videos

Last Updated: May 27, 2025

Author Spotlight: Computing the Effects of a Local Radiofrequency Hyperthermia Intervention on Tumor Biomechanics
10:23

Author Spotlight: Computing the Effects of a Local Radiofrequency Hyperthermia Intervention on Tumor Biomechanics

Published on: December 1, 2023

349
Thermal Ablation for the Treatment of Abdominal Tumors
07:16

Thermal Ablation for the Treatment of Abdominal Tumors

Published on: March 7, 2011

34.3K
Emission Spectroscopic Boundary Layer Investigation during Ablative Material Testing in Plasmatron
09:41

Emission Spectroscopic Boundary Layer Investigation during Ablative Material Testing in Plasmatron

Published on: June 9, 2016

12.3K

Area of Science:

  • Cardiology
  • Oncology
  • Biomedical Engineering

Background:

  • Pulsed field ablation (PFA) is considered non-thermal, but thermal effects have been observed in clinical applications.
  • The specific parameters influencing thermal energy generation during PFA remain incompletely understood.

Purpose of the Study:

  • To numerically assess the thermal effects of PFA on myocardial and esophageal tissues.
  • To investigate the influence of varying peak voltage conditions on thermal energy development during PFA.

Main Methods:

  • A 3D computer model of the left atrium was utilized to quantify thermal effects.
  • PFA was simulated using a bipolar configuration with specific electrical boundary conditions.
  • A monophasic waveform (100 μs pulse width, 1 s gap) was applied for 50 pulses at 1, 1.5, and 2 kV.

Main Results:

  • Minimal esophageal temperature rise was observed at 1 kV (214.5 J).
  • Temperatures reached 46.3°C and >62°C at 1.5 kV (570.3 J) and 2 kV (1.23 kJ) after a single pulse train, respectively.
  • Repeated PFA applications may lead to significant temperature increases, especially with good tissue contact.

Conclusions:

  • Thermal effects in PFA are dependent on total energy deposited, with peak voltage being a key determinant.
  • Current PFA systems may induce collateral thermal injury with repeated use.
  • Careful monitoring and adjustment of PFA parameters are crucial in clinical practice.