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Updated: May 27, 2025

Spectrophotometric Screening for Potential Inhibitors of Cytosolic Glutathione S-Transferases
Published on: October 10, 2020
Glutathione in the Biosynthesis of Glutazoline Teredinibactins
Youjung Sung1, Bailey W Miller1, Eric W Schmidt1
1Department of Medicinal Chemistry, University of Utah, Salt Lake City, Utah 84112, United States.
Abstract:
Teredinibactins are β-resorcyclic thiazoline dipeptides synthesized by Teredinibacter turnerae T7901, a bacterial symbiont of shipworms in the sea. Through feeding studies, we show that the thiazoline moiety is made from glutathione and its metabolites in a noncanonical pathway, for which we suggest the name "glutazoline". Mimicking the biosynthetic reaction, we synthesized both natural and unnatural teredinibactins. The results expand the scope of biological and chemical approaches to aromatic azoline conjugates.
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