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High Rates of "Watch" and "Reserve" Class Antibiotics Used to Treat Infections in Neonates and Infants in Southeast

Michelle L Harrison1,2, Benjamin F R Dickson1,2, Maria Esterlita T Villanueva-Uy3,4

  • 1From the Sydney Institute for Infectious Diseases, The University of Sydney.

The Pediatric Infectious Disease Journal
|February 17, 2025
PubMed

Insights

Antibiotic prescribing for hospitalized infants in Southeast Asia frequently involved high-risk medications. This practice contributes to antimicrobial resistance, impacting infant health in resource-limited settings.

Area of Science:

  • Global Health
  • Infectious Diseases
  • Pharmacology

Background:

  • Antimicrobial resistance (AMR) poses a significant threat to neonatal and infant health, particularly in resource-constrained settings.
  • Infections in hospitalized neonates and infants are common, necessitating antibiotic treatment.

Purpose of the Study:

  • To evaluate antibiotic prescribing patterns for hospitalized neonates and infants in Southeast Asia.
  • To identify the types of antibiotics used and assess their appropriateness in resource-limited healthcare environments.

Main Methods:

  • A point prevalence survey was conducted across 10 clinical sites in Southeast Asia.
  • Data were collected on 667 admitted infants, with a focus on antibiotic prescriptions.

Main Results:

  • A total of 405 antibiotic courses were prescribed to 218 infants.
  • A high proportion of prescribed antibiotics were classified by the World Health Organization as "Watch," "Reserve," or "Not Recommended."

Conclusions:

  • Antibiotic prescribing for hospitalized infants in resource-limited Southeast Asian settings is characterized by high utilization of higher-risk antibiotics.
  • These prescribing practices may exacerbate antimicrobial resistance, contributing to significant infant morbidity and mortality.

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