Related Experiment Video
Updated: May 27, 2025

A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting
Published on: January 12, 2018
Reducing prematurity-related neonatal mortality: a quality improvement project in Gandhi Memorial Hospital, Addis
Biniam Yohannes Wotango1, Wubet Mihretu Workneh2, Tariku Deressa Abdana2
1Gandhi Memorial Hospital, Addis Ababa, Ethiopia biniamy50@gmail.com.
Insights
Neonatal deaths due to prematurity were reduced by 25.6% at Gandhi Memorial Hospital. Interventions included CPAP transport, enhanced CPAP device use, and infection control, significantly improving infant survival rates.
Area of Science:
- Neonatal care
- Quality improvement in healthcare
- Public health
Background:
- Neonatal deaths constitute nearly 50% of global under-five child mortality.
- Preterm birth is the leading cause of neonatal mortality, leading to complications like respiratory distress syndrome and sepsis.
- Gandhi Memorial Hospital faced a high neonatal mortality rate, with 57.7% of deaths linked to prematurity-related issues and a 20.7% baseline mortality for premature neonates in the NICU.
Purpose of the Study:
- To decrease neonatal mortality associated with prematurity at Gandhi Memorial Hospital.
- To implement and evaluate targeted interventions to improve outcomes for premature infants.
Main Methods:
- A multidisciplinary team utilized a fishbone diagram to identify causes of prematurity-related neonatal deaths.
- The Institute for Healthcare Improvement (IHI) model, incorporating Plan-Do-Study-Act cycles, guided the quality improvement process.
- Key interventions included CPAP transport for neonates, enhanced use of CPAP devices with integrated oxygen systems, and implementation of a four-component infection prevention checklist.
Main Results:
- The implementation of three interventions led to a 25.6% reduction in prematurity-related neonatal mortality.
- Run chart analysis demonstrated a statistically significant decrease in mortality rates, shifting below the baseline median.
Conclusions:
- The quality improvement project successfully reduced prematurity-related neonatal deaths at Gandhi Memorial Hospital through targeted interventions.
- Recommendations include standardizing CPAP transport protocols, optimizing CPAP device usage in NICUs, and ensuring full implementation of infection prevention checklists to enhance neonatal outcomes.
Background:
Neonatal deaths refer to infants who die within the first 28 days of life, and they account for almost 50% of all child deaths under the age of 5 globally. Preterm birth is the primary reason for neonatal deaths, and it can lead to various complications that may prove fatal for newborns, such as respiratory distress syndrome, sepsis and intracranial haemorrhages. There was a high rate of neonatal mortality at Gandhi Memorial Hospital. 57.7% of neonatal deaths were caused by premature-related problems according to Pareto chart analysis. The baseline mortality rate among premature neonates admitted to the Neonatal Intensive Care Unit (NICU) was 20.7%. The objective of this quality improvement project was to reduce prematurity-related neonatal death at Gandhi Memorial Hospital.
Methods:
A multidisciplinary quality improvement team used a fishbone diagram to analyse the causes of neonatal deaths related to prematurity. We used the Institute for Healthcare Improvement (IHI) model for improvement, using Plan-Do-Study-Act cycles to measure progress and make data-driven decisions.
Interventions:
Transporting premature neonates born in the labour ward to NICU with CPAP, increasing the use of a continuous positive airway pressure (CPAP) device with an integrated oxygen concentrator, blender and compressor, and implementing the infection prevention checklist with four components were the implemented change ideas.
Results:
The run chart showed a 25.6% reduction in prematurity-related neonatal mortality after implementing three interventions, and evidenced by a shift below the baseline median.
Conclusion And Recommendation:
The quality improvement project involving three interventions which are transporting premature neonates from labour ward to NICU with CPAP, using a CPAP device with an integrated oxygen concentrator, blender and compressor for preterm neonates and infection prevention checklist use with four components at Gandhi Memorial Hospital effectively reduced prematurity-related neonatal death. To improve neonatal outcome in premature neonates, we recommend that hospitals should prioritise implementing a standardised CPAP transport protocol, increasing a CPAP device with an integrated oxygen concentrator, blender and compressor use in the NICU, and fully implementing the infection prevention Checklist.

