Related Experiment Video
Updated: May 27, 2025
05:55
Delivery of Therapeutic Agents Through Intracerebroventricular ICV and Intravenous IV Injection in Mice
Published on: October 3, 2011
59.7K
Therapeutic delivery - industry update covering October 2024
1Global Pharma Segment, Phillips Medisize, Cambridge, UK.
Therapeutic Delivery
|February 17, 2025
Summary
Biopharma companies acquired two biotech firms, advanced drug delivery technologies, and received regulatory approvals for new treatments. Key developments include novel subcutaneous and nasal delivery systems, and progress in gene therapy and targeted drug delivery research.
Area of Science:
- Biopharmaceutical industry
- Drug delivery technologies
- Therapeutic applications
Background:
- Merck acquired Modifi Biosciences for small molecule anticancer therapeutics.
- AbbVie acquired Aliada Therapeutics for central nervous system disorder treatments.
- GSK and Cambridge University initiated a five-year collaboration for kidney and respiratory diseases.
Discussion:
- Elektrofi and Archon Biosciences secured investments for advanced drug delivery systems.
- Aeropump and Resyca launched a novel soft mist nasal delivery system.
- UCB and AbbVie received FDA approvals for enhanced drug formulations and delivery methods.
Key Insights:
- Eisai submitted a subcutaneous formulation of an Alzheimer's therapy to the FDA.
- Lilly reported positive results for a modified dosing regimen of its Alzheimer's drug, Kisunla (donanemab).
- Johnson and Johnson terminated a Phase III trial for a bladder cancer device.
Outlook:
- Developments in controlled antibiotic delivery, gene therapy delivery systems, and robotic targeted drug delivery were highlighted.
- The PDA Universe of Prefilled Syringes conference showcased advancements in injectable drug delivery.
- Ongoing research focuses on improving therapeutic efficacy and patient compliance through innovative delivery mechanisms.
Related Concept Videos
01:16Drug Delivery: Overview
271
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
271
01:26Drug Administration and Therapy Phases: Overview
403
Drugs, the chemical agents used in diagnosing, treating, or preventing diseases, undergo a four-phase process of development: pharmaceutic, pharmacokinetics, pharmacodynamics, and therapeutic.
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
The pharmacokinetic phase...
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
The pharmacokinetic phase...
403
01:29Issues And Trends In Healthcare Delivery System
5.6K
The issues and trends in healthcare delivery are constantly changing. The COVID-19 pandemic is one recent issue that wreaked havoc on healthcare systems, causing a shortage of healthcare workers, high demand for medicines and supplies, and increased medical expenditure due to a lack of insurance. Other issues include rising healthcare costs and care fragmentation.
Cost Containment
Payment for healthcare services has historically promoted adoption of costly and often unnecessary or inefficient...
Cost Containment
Payment for healthcare services has historically promoted adoption of costly and often unnecessary or inefficient...
5.6K
01:22Drug Delivery: Miscellaneous Routes
303
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
303
01:11Clinical Trials: Overview
2.7K
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
2.7K
01:29Drug Delivery: Parenteral Route
374
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
374