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Updated: May 27, 2025
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Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma
Published on: September 15, 2023
710
Study Protocol of Expanded Multicenter Prospective Cohort Study of Active Surveillance on Papillary Thyroid
Jae Hoon Moon1, Eun Kyung Lee2,3, Wonjae Cha4
1Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.
Endocrinology and Metabolism (Seoul, Korea)
|February 17, 2025
Summary
Active surveillance (AS) is a safe option for low-risk papillary thyroid microcarcinoma (PTMC). The MAeSTro-EXP study expands AS to larger tumors, aiming to reduce unnecessary surgeries and improve patient outcomes globally.
Area of Science:
- Oncology
- Endocrinology
- Surgical Oncology
Background:
- Active surveillance (AS) is established for low-risk papillary thyroid microcarcinoma (PTMC).
- Previous studies, including MAeSTro, have validated AS, influencing international guidelines.
- MAeSTro-EXP extends AS to larger low-risk papillary thyroid carcinomas (PTCs), challenging size-based surgical criteria.
Purpose of the Study:
- To evaluate expanding AS criteria for low-risk PTCs beyond 1 cm.
- To refine risk assessment and disease progression criteria for AS.
- To minimize overtreatment in low-risk PTC management.
Main Methods:
- Expanding AS eligibility to include low-risk PTCs up to 1.5 cm.
- Standardizing risk stratification and progression monitoring protocols.
- Conducting a multinational collaboration between South Korea and Australia.
Main Results:
- The study hypothesizes that risk assessment is more critical than tumor size for AS eligibility.
- Refined criteria aim to prevent unnecessary surgeries during early tumor growth.
- Data will inform optimized AS guidelines for low-risk PTCs.
Conclusions:
- This research will optimize AS guidelines for low-risk PTCs.
- It enhances understanding of PTC natural history and management.
- The multinational aspect will reveal cultural and racial influences on AS practices.
