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10:28
Biological Compatibility Profile on Biomaterials for Bone Regeneration
Published on: November 16, 2018
12.4K
Development of fully-resorption replacement paste-like organic/inorganic artificial bones compatible with bone
Yuki Kamaya1, Shiori Kato1, Kazuaki Nakano2
1Department of Applied Chemistry, School of Science and Technology, Meiji University, 1-1-1 Higashimita, Tama-ku, Kawasaki 214-8571, Kanagawa, Japan.
Biomaterials and Biosystems
|February 18, 2025
Summary
This study optimized a new bioresorbable tricalcium β-phosphate (β-TCP) cement for bone grafting. A 5% poly(lactic-co-glycolic acid) (PLGA) hybrid formulation demonstrated the best balance of resorption and bone formation in animal models.
Area of Science:
- Biomaterials Science
- Orthopedic Surgery
- Regenerative Medicine
Background:
- Conventional calcium-phosphate cements (CPCs) set to hydroxyapatite (HAp), offering limited bioresorbability.
- Enhancing bioresorbability is crucial for bone graft substitutes to support natural bone remodeling.
Purpose of the Study:
- To develop and evaluate a novel, bioresorbable, chelate-setting tricalcium β-phosphate (β-TCP) cement.
- To optimize the content of poly(lactic-co-glycolic acid) (PLGA) particles for enhanced resorption and bone regeneration.
Main Methods:
- An organic/inorganic hybrid cement was formulated using β-TCP, inositol phosphate (IP6), PLGA, and calcium sulfate hemihydrate (CSH).
- Cement properties (setting time, compressive strength) and cytotoxicity were assessed.
- In vivo studies in a pig tibia model evaluated the effects of varying PLGA concentrations (5, 10, 20 mass%) on resorption and bone formation.
Main Results:
- The hybrid cement exhibited a compressive strength of ~30 MPa and set within 15 minutes.
- Cytotoxicity tests confirmed cell viability with all cement formulations.
- The 5 mass% PLGA formulation showed the highest bone formation rate, while higher PLGA amounts increased resorption but impaired bone regeneration.
Conclusions:
- A β-TCP cement incorporating 5 mass% PLGA and CSH offers an optimal balance between material resorption and bone regeneration.
- This hybrid cement formulation shows promise as a fully absorbable, paste-type bone graft substitute supporting bone remodeling.
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