Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Advancing maternal age worsens pregnancy outcomes following single frozen embryo transfer with preimplantation genetic testing.

Reproductive biomedicine online·2026
Same author

Trigger-day hCG effects on DNA methylation and neurodevelopment in ART offspring.

Nature communications·2026
Same author

Interventions for Silent Brain Infarction and Perioperative Neurocognitive Disorders in Cardiovascular Surgery (INSPIRE): study protocol for a multicentre randomised controlled trial.

BMJ open·2026
Same author

Comment on: 'Treatment patterns and long-term outcomes in anti-VEGF-treated macular oedema secondary to retinal vein occlusion: a retrospective observational study'.

Eye (London, England)·2026
Same author

Spatially interpretable artificial intelligence framework to tailored neoadjuvant dual HER2 blockade in HER2-positive breast cancer.

Signal transduction and targeted therapy·2026
Same author

Socioeconomic disparities and health-related parenting practices in shaping early infant neurodevelopment: evidence from a Chinese prospective birth cohort.

BMC pregnancy and childbirth·2026

Related Experiment Video

Updated: May 27, 2025

A Model for Epilepsy of Infectious Etiology using Theiler's Murine Encephalomyelitis Virus
05:33

A Model for Epilepsy of Infectious Etiology using Theiler's Murine Encephalomyelitis Virus

Published on: June 23, 2022

2.7K

A New Mouse Model for Exploring Tranexamic Acid-Associated Seizures.

Jingjia Shen1, Yue Liu2, Xudong Liao3

  • 1From the Department of Anesthesiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Anesthesia and Analgesia
|February 18, 2025
PubMed
Summary

This study establishes an in vivo mouse model for tranexamic acid-induced seizures (TXA-IS), detailing its behavioral, EEG, histological, and metabolomic characteristics for research.

More Related Videos

Generation and On-Demand Initiation of Acute Ictal Activity in Rodent and Human Tissue
06:45

Generation and On-Demand Initiation of Acute Ictal Activity in Rodent and Human Tissue

Published on: January 19, 2019

8.9K
Inducing Post-Traumatic Epilepsy in a Mouse Model of Repetitive Diffuse Traumatic Brain Injury
07:07

Inducing Post-Traumatic Epilepsy in a Mouse Model of Repetitive Diffuse Traumatic Brain Injury

Published on: February 10, 2020

10.4K

Related Experiment Videos

Last Updated: May 27, 2025

A Model for Epilepsy of Infectious Etiology using Theiler's Murine Encephalomyelitis Virus
05:33

A Model for Epilepsy of Infectious Etiology using Theiler's Murine Encephalomyelitis Virus

Published on: June 23, 2022

2.7K
Generation and On-Demand Initiation of Acute Ictal Activity in Rodent and Human Tissue
06:45

Generation and On-Demand Initiation of Acute Ictal Activity in Rodent and Human Tissue

Published on: January 19, 2019

8.9K
Inducing Post-Traumatic Epilepsy in a Mouse Model of Repetitive Diffuse Traumatic Brain Injury
07:07

Inducing Post-Traumatic Epilepsy in a Mouse Model of Repetitive Diffuse Traumatic Brain Injury

Published on: February 10, 2020

10.4K

Area of Science:

  • Neuroscience
  • Pharmacology
  • Animal Models

Background:

  • Tranexamic acid (TXA) is crucial in antifibrinolytic therapy.
  • TXA use raises concerns about associated seizures.
  • An in vivo model is needed to study TXA-induced seizures (TIS).

Purpose of the Study:

  • To develop and characterize an in vivo mouse model of TXA-induced seizures (TIS).
  • To identify the specific features of TIS in behavior, EEG, histology, and metabolomics.

Main Methods:

  • Adult male C57BL/6J mice received intracerebroventricular injections of TXA at varying doses.
  • Behavioral scoring used the Racine scale for dose titration.
  • Video-EEG, histology, and metabolomic analyses were performed on TIS and control groups.

Main Results:

  • A dose of 7.5 μg/μL TXA induced intense behavioral seizures and epileptic EEG discharges.
  • Histology revealed hippocampal CA3 neuronal necrosis and loss.
  • Metabolomics showed disturbances in amino acid, energy, and antioxidant metabolism.

Conclusions:

  • An in vivo mouse model for TXA-induced seizures (TIS) was successfully developed.
  • The model exhibits distinct behavioral, EEG, histological, and metabolomic features.
  • This model aids in understanding TXA-associated seizure mechanisms.