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Updated: May 27, 2025
Tissue-simulating Phantoms for Assessing Potential Near-infrared Fluorescence Imaging Applications in Breast Cancer Surgery
Published on: September 19, 2014
Multispectral Imaging of Intrinsic Metabolic Fluorophores: Detection of Human Breast Cancer in Fresh Ex Vivo
Gary E Carver1, Mark D Entwistle2, Prachi N Ghule3
1Department of Biochemistry, University of Vermont, Burlington, VT 05405, USA.
Abstract:
A growing number of women develop breast cancer and require surgery. Many lumpectomies lead to follow-up procedures after the initial surgery. Advanced scanning technologies have reduced the number of second and third surgeries, but only by about 50%. This paper assesses the potential of using multispectral images of intrinsic fluorescence to detect breast cancer. Images and spectra of intrinsic fluorescence from fresh ex vivo human specimens are related to pathological analysis, and predict high sensitivity and specificity. A design for a hand-held surgical scanning tool is presented.
