Related Experiment Video
Updated: May 27, 2025
10:21
Author Spotlight: Streamlining Protein Target Prediction and Validation via Molecular Docking and CETSA
Published on: February 23, 2024
2.3K
Artificial Intelligence for Drug Discovery: An Update and Future Prospects.
Harrison J Howell1, Jeremy P McGale1, Aurélie Choucair2
1Department of Radiology, New York-Presbyterian Hospital, Columbia University Vagelos College of Physicians and Surgeons, New York, NY.
Seminars in Nuclear Medicine
|February 18, 2025
Summary
Artificial intelligence (AI) enhances medical imaging analysis for drug discovery. AI improves diagnostics, biomarker identification, and trial efficiency, accelerating the development of new pharmaceuticals.
Area of Science:
- Medical Imaging
- Artificial Intelligence
- Drug Discovery
Background:
- Artificial intelligence (AI) is transforming medical image analysis.
- AI enhances diagnostics, staging, prognostication, and response assessment in healthcare.
Purpose of the Study:
- To provide a comprehensive overview of AI's role in enhancing medical imaging for drug development.
- To highlight how AI accelerates pharmaceutical research and therapeutic strategy formulation.
Main Methods:
- AI enables quantification and synthesis of qualitative imaging characteristics.
- AI facilitates identification of novel biomarkers and patient risk stratification.
- AI assists in response assessment by analyzing longitudinal changes in imaging phenotypes.
Main Results:
- AI integration into drug discovery pipelines accelerates identification and development of new pharmaceuticals.
- AI aids in target identification and patient selection for clinical trials.
- AI reduces trial failures through high-throughput, reproducible, data-driven insights.
Conclusions:
- AI applications in medical imaging are crucial for efficient, accurate, and tailored drug discovery.
- Continued progress in AI will significantly shape the future of pharmaceutical development.
- AI fosters optimized treatment plans and reduces the cost of failed drug trials.
More Related Videos
Related Concept Videos
01:26Drug Discovery: Overview
7.4K
Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
7.4K
01:28Structure-Activity Relationships and Drug Design
488
Drug design is a dynamic field that involves discovering and developing new medications based on specific biological targets. This process heavily relies on structure-activity relationships (SAR) and quantitative structure-activity relationships (QSAR) to guide the design and optimization of efficient drugs.
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence...
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence...
488
01:26Drug Administration and Therapy Phases: Overview
403
Drugs, the chemical agents used in diagnosing, treating, or preventing diseases, undergo a four-phase process of development: pharmaceutic, pharmacokinetics, pharmacodynamics, and therapeutic.
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
The pharmacokinetic phase...
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
The pharmacokinetic phase...
403
01:24Principles of Drug Action
5.7K
Drugs are chemical substances that modify biological responses by interacting with macromolecular targets such as receptors, ion channels, transporters, and enzymes. Pharmacodynamics describes the course of action of drugs leading to the physiological effect at a specific site in the body.
Drugs can be agonists or antagonists. Like the endogenous ligands, agonists always bind and activate the target to produce a cellular response. Agonist binding induces a conformational change which in turn...
Drugs can be agonists or antagonists. Like the endogenous ligands, agonists always bind and activate the target to produce a cellular response. Agonist binding induces a conformational change which in turn...
5.7K
01:28Preclinical Development: Overview
4.2K
Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
4.2K
02:04Protein-protein Interfaces
12.4K
Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
12.4K