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Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder
Published on: January 9, 2015
Multiple forms of discrimination and obsessive-compulsive disorder: a prospective cohort study
Jason M Nagata1, Jonanne Talebloo2, Thang Diep2
1Department of Pediatrics, University of California, San Francisco, 550 16th Street, 4th Floor, Box 0503, San Francisco, CA, 94143, USA. jason.nagata@ucsf.edu.
Discrimination in early adolescence, particularly multiple forms, racial, sexual orientation, and weight-based, significantly increases the risk for developing obsessive-compulsive disorder (OCD). Early screening for OCD is recommended for adolescents who have faced discrimination.
Area of Science:
- Adolescent mental health
- Psychiatry
- Sociology
Background:
- Discrimination is a known risk factor for adverse mental health outcomes.
- Studies indicate higher rates of obsessive-compulsive disorder (OCD) in Black adults experiencing racial discrimination.
- Longitudinal research on various forms of discrimination and OCD risk in early adolescence is limited.
Purpose of the Study:
- To investigate the prospective associations between multiple forms of discrimination and the risk of developing OCD in early adolescents.
- To analyze data from a national sample of U.S. early adolescents.
Main Methods:
- Prospective cohort data from the Adolescent Brain Cognitive Development Study (N=7,983) across two years (ages 10-13 and 11-14) were analyzed.
- Multiple logistic regression models were employed to assess associations between past-year discrimination experiences (race/ethnicity, country of origin, sexual orientation, weight, multi-discrimination) and probable OCD at follow-up.
- Models were adjusted for relevant covariates including demographics, socioeconomic status, and baseline mental health indicators.
Main Results:
- Multi-discrimination (OR=1.67), racial discrimination (OR=2.77), sexual orientation discrimination (OR=2.51), and weight discrimination (OR=2.51) were significantly associated with a higher likelihood of probable OCD at follow-up.
- No significant association was found for discrimination based on country of origin.
- These associations remained significant after adjusting for all covariates.
Conclusions:
- Experiencing multiple forms of discrimination during early adolescence is linked to an increased risk of developing probable OCD.
- Findings support the importance of screening for OCD in young adolescents who have encountered discrimination.
- Educators and healthcare providers should guide adolescents experiencing discrimination toward mental health resources.
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