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Cyclic Peptides Targeting Granzyme B: Potential Applications as PET Imaging Agents

Qi-Long Hu1, Steven H Liang1

  • 1Department of Radiology and Imaging Sciences, Emory University, Atlanta, Georgia 30322, United States.

ACS Medicinal Chemistry Letters
|February 19, 2025
PubMed
Summary

This patent reveals macrocyclic peptides that bind to Granzyme B (GzmB), enabling imaging of diseases linked to elevated GzmB. These peptides offer potential for diagnosing conditions like cancer immunotherapy, autoimmunity, and inflammation.

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Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
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