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Performance of α-Defensins in Diagnosing Nosocomial Ventriculitis
Max W Jacobs1,2, James B Doub1,2
1The Doub Laboratory of Translational Bacterial Research, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Open Forum Infectious Diseases
|February 19, 2025
Abstract:
Nosocomial ventriculitis can be an extremely difficult infectious disease process to diagnose, thereby exposing patients to increased morbidity and unwarranted aggressive antibiotics. Thus, novel ventriculitis diagnostics are drastically needed. In this study, we demonstrate excellent sensitivity and specificity of cerebral spinal fluid α-defensins to aid in diagnosing ventriculitis.

