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Synthesis of Functionalized Thioimidates from Thioamides and Arylboronic Acids via Copper-Catalyzed Cross-Coupling
Nitin Kumar1, Sundaram Singh1, Jeyakumar Kandasamy1,2
1Department of Chemistry, Indian Institute of Technology (BHU), Varanasi 221005, Uttar Pradesh, India.
Abstract:
Functionalized S-aryl thioimidates were synthesized from thioamides and arylboronic acids at room temperature under mild conditions. The reaction was catalyzed by copper(II) acetate in the presence of DBU under an open atmosphere. A wide range of functionalized aryl and alkyl boronic acids was chemo-selectively coupled with aryl and alkyl thioamides to obtain corresponding S-aryl and S-alkyl thioimidates in 64-80% yields. Room temperature reactions, easy operation, and broad substrate scope are the salient features of the developed methodology.
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