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Related Experiment Videos

Subretinal strands: ultrastructural features.

M T Trese, D B Chandler, R Machemer

    Graefe'S Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie
    |January 1, 1985
    PubMed
    Summary
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    Subretinal strands in retinal detachment feature retinal pigment epithelial cells and collagen. These findings offer insights into proliferative vitreoretinopathy, aiding surgical interventions.

    Area of Science:

    • Ophthalmology
    • Cell Biology
    • Histology

    Background:

    • Proliferative vitreoretinopathy (PVP) is a severe complication of retinal detachment.
    • Subretinal strands are a key feature in PVP, contributing to retinal distortion and vision loss.

    Purpose of the Study:

    • To elucidate the histologic and ultrastructural composition of subretinal strands.
    • To identify cellular and extracellular matrix components within these strands.

    Main Methods:

    • Histologic examination of 13 subretinal strands.
    • Ultrastructural analysis using electron microscopy.

    Main Results:

    • Subretinal strands contain surface retinal pigment epithelial (RPE) cells and internal modified RPE cells.

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  • Internal components include fibroblasts, myofibroblasts, macrophages, collagen, fibrin, and basal lamina material.
  • Basal lamina material in some strands resembles that found in drusen and Bruch's membrane.

    • Conclusions:

    • Subretinal strands are complex structures composed of RPE cells and extracellular matrix, indicative of a wound-healing response.
    • Understanding strand composition aids in managing proliferative vitreoretinopathy and improving surgical outcomes.