Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pathophysiology of Peptic Ulcer Disease: Injurious Factors01:22

Pathophysiology of Peptic Ulcer Disease: Injurious Factors

1.6K
Peptic ulcers are sores on the stomach's inner lining and the upper small intestine, which are the result of disruptions in the mucosal layer that houses parietal cells which produce gastric acid, and chief cells which secrete pepsinogen.
In the antrum region, G cells secrete the gastrin hormone that binds to gastrin-cholecystokinin-B (CCK2) receptors on parietal and enterochromaffin-like (ECL) cells in the fundic glands. Simultaneously, the vagus nerve releases acetylcholine, which binds...
1.6K
Peptic Ulcer Disease I: Introduction01:30

Peptic Ulcer Disease I: Introduction

1.2K
Peptic Ulcer Disease (PUD) is characterized by mucosal excavation in the esophagus, stomach, pylorus, or duodenum. It can manifest as acute or chronic based on the extent and duration of mucosal involvement.
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
1.2K
Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies01:28

Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies

1.0K
Peptic ulcer disease (PUD) presents with diverse symptoms depending on the location and severity of the ulcer. Clinical manifestations of peptic ulcer include dull pain and a burning sensation in the mid-epigastric region.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
1.0K
Peptic Ulcer Disease IV: Management01:26

Peptic Ulcer Disease IV: Management

807
Medical treatment strategies for peptic ulcers encompass various methods. The primary goal of treatment is to diminish gastric acidity and strengthen mucosal defense mechanisms.
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
807
Peptic Ulcer Disease I: Introduction01:25

Peptic Ulcer Disease I: Introduction

28
Peptic ulcer disease (PUD) involves breaks in the gastrointestinal tract's mucosal lining, primarily in the stomach and duodenum, with less frequent occurrences in the lower esophagus or near the pylorus.Ulcers can be acute or chronic. Acute ulcers are short-lived with minimal inflammation and heal quickly after the irritant is removed. Chronic ulcers persist, may recur, and often cause scarring due to ongoing tissue damage. Superficial erosions affect only the mucosal layer and are called...
28
Peptic Ulcer Disease III: Clinical Manifestations and Complications01:25

Peptic Ulcer Disease III: Clinical Manifestations and Complications

38
Duodenal UlcersDuodenal ulcers are the most common form of peptic ulcer disease, presenting with chronic, intermittent epigastric pain. Pain typically appears 2–3 hours after meals, especially when the stomach is empty, often waking patients at night. It is characteristically relieved by food or antacids (“pain–food–relief”). Some patients remain asymptomatic until complications like bleeding or perforation emerge, particularly with NSAID or anticoagulant...
38

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Author Correction: Large language models and agricultural extension services.

Nature food·2023
Same author

Large language models and agricultural extension services.

Nature food·2023
Same author

Visualization of Chiral Electronic Structure and Anomalous Optical Response in a Material with Chiral Charge Density Waves.

Physical review letters·2022
Same author

Early efficacy and safety data with fixed-dose combination calcipotriol/betamethasone dipropionate foam attributed to mechanism of absorption and steroid potency.

Journal of the European Academy of Dermatology and Venereology : JEADV·2021
Same author

Applying the principle 'First Do No Harm' during the pandemic.

BJOG : an international journal of obstetrics and gynaecology·2020
Same author

Indirubin: a novel topical agent in the treatment of psoriasis.

The British journal of dermatology·2018

Related Experiment Video

Updated: May 3, 2026

Author Spotlight: Advancing Early Detection and Treatment of Gastrointestinal Tumors
03:05

Author Spotlight: Advancing Early Detection and Treatment of Gastrointestinal Tumors

Published on: February 16, 2024

1.9K

Gastrin sensitivity in duodenal ulcer.

S K Lam, J Koo

    Gut
    |May 1, 1985
    PubMed
    Summary

    Gastrin hypersensitivity is a common abnormality in duodenal ulcer patients. Genetic and environmental factors influence this sensitivity, affecting disease onset and familial history.

    Area of Science:

    • Gastroenterology
    • Physiology
    • Genetics

    Background:

    • Duodenal ulcers are a significant gastrointestinal condition.
    • Pentagastrin stimulates gastric acid output, and its sensitivity can be a key indicator.
    • Understanding factors influencing acid production is crucial for duodenal ulcer management.

    Purpose of the Study:

    • To investigate pentagastrin sensitivity (D50C) in duodenal ulcer patients.
    • To explore the relationship between D50C, age of onset, and familial history.
    • To identify potential genetic and environmental influences on gastrin sensitivity in duodenal ulcers.

    Main Methods:

    • Measured D50C (dose for half maximal acid output) in 200 duodenal ulcer patients and 36 controls.
    • Analyzed D50C distribution based on age of onset (early vs. late).

    More Related Videos

    Author Spotlight: Gastric Epithelial Cell Responses in Helicobacter pylori infection
    08:24

    Author Spotlight: Gastric Epithelial Cell Responses in Helicobacter pylori infection

    Published on: July 5, 2024

    1.2K
    Gastric Mucosa Quantitative Polymerase Chain Reaction Analysis for Detecting Helicobacter pylori and Antibiotic Resistance
    05:23

    Gastric Mucosa Quantitative Polymerase Chain Reaction Analysis for Detecting Helicobacter pylori and Antibiotic Resistance

    Published on: March 7, 2025

    891

    Related Experiment Videos

    Last Updated: May 3, 2026

    Author Spotlight: Advancing Early Detection and Treatment of Gastrointestinal Tumors
    03:05

    Author Spotlight: Advancing Early Detection and Treatment of Gastrointestinal Tumors

    Published on: February 16, 2024

    1.9K
    Author Spotlight: Gastric Epithelial Cell Responses in Helicobacter pylori infection
    08:24

    Author Spotlight: Gastric Epithelial Cell Responses in Helicobacter pylori infection

    Published on: July 5, 2024

    1.2K
    Gastric Mucosa Quantitative Polymerase Chain Reaction Analysis for Detecting Helicobacter pylori and Antibiotic Resistance
    05:23

    Gastric Mucosa Quantitative Polymerase Chain Reaction Analysis for Detecting Helicobacter pylori and Antibiotic Resistance

    Published on: March 7, 2025

    891
  • Correlated D50C with maximal acid output (MAO) and familial ulcer dyspepsia history.

    • Main Results:

    • Duodenal ulcer patients showed significantly higher pentagastrin sensitivity (D50C) than controls.
    • 27% of patients had D50C above the normal limit.
    • Sensitivity varied significantly between early and late onset patients, influenced by MAO levels and familial history.

    Conclusions:

    • Increased gastrin sensitivity is a distinct physiological abnormality in duodenal ulcers.
    • Genetic factors may underlie increased sensitivity in some patients with normal MAO and late onset.
    • Environmental factors, potentially early in life, may contribute to increased sensitivity in patients with high MAO and early onset.