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Updated: May 27, 2025
10:39
A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae
Published on: September 17, 2020
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[Multi-Omic Rejuvenation: A New Strategy for Lifespan Extension]
O Y Rybina1,2, E G Pasyukova1
1National Research Center "Kurchatov Institute", Moscow, 123182 Russia.
Molekuliarnaia Biologiia
|February 19, 2025
Summary
Aging leads to tissue decline and disease. Multi-omic rejuvenation technologies, like reprogramming cells, show promise in reversing age-related changes and extending lifespan by restoring youthful molecular patterns.
Area of Science:
- Gerontology and Molecular Biology
- Investigating the molecular underpinnings of aging and developing interventions.
Background:
- Aging is characterized by progressive molecular and functional decline across multiple biological systems.
- Age-related changes in the transcriptome, proteome, metabolome, and epigenome contribute to disease risk and mortality.
- The microbiome also dynamically changes with age, influencing host gene expression and metabolism.
Purpose of the Study:
- To review current multi-omic rejuvenation technologies.
- To discuss the potential of these technologies for extending and improving healthspan.
- To highlight the molecular basis of age-related decline and rejuvenation.
Main Methods:
- Review of recent scientific literature on aging and rejuvenation.
- Analysis of multi-omic data (transcriptome, epigenome, proteome, metabolome, microbiome).
- Focus on rejuvenation strategies involving cellular reprogramming and gene expression modulation.
Main Results:
- Multi-omic rejuvenation technologies demonstrate efficacy in decreasing age-related disorders.
- Short-term induction of reprogramming factors restores youthful epigenetic and transcriptomic profiles.
- These interventions have been linked to increased lifespan in model systems.
Conclusions:
- Multi-omic approaches offer a powerful strategy to combat age-related decline.
- Cellular reprogramming holds significant potential for therapeutic interventions in aging.
- Further research into these technologies could lead to improved longevity and healthspan.
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