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Updated: May 27, 2025

A Murine Model of Group B Streptococcus Vaginal Colonization
Published on: November 16, 2016
Gestational diabetes mellitus and Group B streptococci in the urine
Susani R Karkov1, Niels Uldbjerg2, Jens K Møller3
1Department of Gynecology and Obstetrics, Kolding Hospital, University Hospital of Southern, Denmark.
Background:
We hypothesized that gestational diabetes mellitus (GDM) increases the risk of urinary Group B Streptococcus (uGBS) colonization during pregnancy. The primary aim of this study was to compare the incidence of GDM between pregnant women with uGBS and those without uGBS.
Methods:
From a population of 34,285 consecutive singleton pregnancies, we included the women 6,014 tested for uGBS. Of these, 249 were uGBS-positive, and the reminder 5,765 being uGBS-negative. GDM status and secondary outcomes were recorded prospectively, and the analysis included pregestational diabetes, age, parity, BMI, tobacco use, and cystitis during pregnancy as confounders.
Results:
The incidence of GDM was 9.2 % (23 of 249) among uGBS-positive women and 4.1 % (236 of 5,520) among uGBS-negative women, resulting in an odds ratio (OR) of 2.4 (95 % CI: 1.5-3.7) and an adjusted OR of 2.2 (95 % CI: 1.4-3.6).
Conclusion:
GDM may be a risk factor to consider in risk-based screening programs aimed at preventing early-onset GBS disease.
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