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Causal associations between posttraumatic stress disorder and type 2 diabetes
Yuqing Song1,2, Ancha Baranova3,4, Hongbao Cao3
1Institute of Mental Health, Peking University Sixth Hospital, Beijing, 100191, China.
Diabetology & Metabolic Syndrome
|February 19, 2025
Summary
Posttraumatic stress disorder (PTSD) may increase the risk of developing type 2 diabetes (T2D). Individuals with PTSD should be screened for T2D and metabolic syndrome.
Area of Science:
- Psychiatry and Endocrinology
- Genetic Epidemiology
Background:
- High comorbidity exists between Posttraumatic Stress Disorder (PTSD) and Type 2 Diabetes (T2D).
- The causal relationship between PTSD and T2D risk remains unclear.
Purpose of the Study:
- To investigate the bidirectional causal associations between PTSD and T2D using Mendelian randomization (MR).
Main Methods:
- Utilized large-scale Genome-Wide Association Study (GWAS) data from European ancestry.
- Employed Mendelian randomization (MR) analysis to assess causal links.
Main Results:
- Posttraumatic stress disorder (PTSD) was causally associated with increased odds of Type 2 Diabetes (T2D) (OR = 1.04, P = 0.0086).
- No significant causal association was found for T2D influencing PTSD risk.
Conclusions:
- PTSD may represent a causal risk factor for developing T2D.
- Recommends screening for T2D and metabolic syndrome in individuals with PTSD.
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