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Updated: May 27, 2025

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Acute Systemic Sclerosis-Associated Cardiomyopathy That Improved With Glucocorticoids and Cyclophosphamide
Andrew A Gustafson1, Katherine V Trinh1, Jon W Lomasney2
1Northwestern University Feinberg School of Medicine, Division of Hospital Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Systemic sclerosis cardiomyopathy can cause heart failure. This case study shows successful treatment of SSc myopericarditis with cyclophosphamide and glucocorticoids, leading to prolonged recovery.
Area of Science:
- Cardiology
- Rheumatology
- Immunology
Background:
- Systemic sclerosis (SSc) cardiomyopathy affects 7-39% of patients, increasing mortality.
- Limited evidence exists for effective SSc cardiomyopathy treatments.
- Cardiomyopathy in SSc is a significant cause of morbidity and mortality.
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