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Th2-Polarised CD4+ T Cells Enhance Staphylococcus aureus Growth in a 3D Skin Model

Ina Suhrkamp1, Melina Fonfara1, Magdalena Magdalena1

  • 1Department of Dermatology and Allergy, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
|February 20, 2025
PubMed
Summary

No abstract available in PubMed .

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Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...