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Related Concept Videos

Menopause01:28

Menopause

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Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
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Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
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Updated: May 27, 2025

Assessing Iron Deposition in the Brains of 5xFAD Mice by Perls'/DAB Staining
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Cognitive Performance in Relation to Systemic and Brain Iron at Perimenopause.

Amy L Barnett, Michael J Wenger, Pamela Miles

    Medrxiv : the Preprint Server for Health Sciences
    |February 20, 2025
    PubMed
    Summary

    For women in menopause, higher iron status correlates with improved cognitive function and brain dynamics. Addressing iron levels may help alleviate menopausal "brain fog".

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    Area of Science:

    • Neuroscience
    • Iron Metabolism
    • Cognitive Function

    Background:

    • Existing research on iron, cognition, and brain iron in menopausal women is unclear.
    • Menopause involves cessation of monthly blood loss, impacting iron levels.
    • Iron accumulation in the brain over time is linked to neurodegenerative diseases.

    Purpose of the Study:

    • To investigate the relationship between blood iron, brain iron, and cognitive performance in women during menopause.
    • To understand how iron status affects cognitive function and brain dynamics as monthly iron loss ends.

    Main Methods:

    • Non-anemic women with varying iron levels provided blood samples.
    • Brain iron levels were estimated using MRI scans.
    • Cognitive tasks and electroencephalography (EEG) were performed concurrently.

    Main Results:

    • Cognitive performance and brain dynamics positively correlated with iron status, including oxygen transport measures.
    • No correlation was found between blood iron measures and brain iron levels.
    • Higher iron status was linked to better cognitive performance in non-anemic women.

    Conclusions:

    • Elevated iron status, not necessarily blood iron levels, is associated with enhanced cognitive function in menopausal women.
    • There is no evidence that higher systemic iron leads to higher brain iron.
    • Targeting low iron levels during menopause may help reduce "brain fog".