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A Comprehensive Review of Current Approaches in Bladder Cancer Treatment
Soniya Kumbham1, Kazi Md Mahabubur Rahman1, Barbara A Foster2
1Department of Pharmaceutical Sciences, University at Buffalo, The State University of New York, Buffalo, New York 14214, United States.
ACS Pharmacology & Translational Science
|February 20, 2025
Summary
Bladder cancer management needs improvement, as current treatments impact quality of life. New diagnostic and therapeutic strategies offer hope for better patient outcomes and reduced healthcare costs.
Area of Science:
- Urology
- Oncology
- Cancer Research
Background:
- Bladder cancer is a prevalent and costly malignancy within the urinary system.
- Current treatment advancements have not proportionally improved patient quality of life.
- There is a critical need for novel bladder cancer management strategies.
Purpose of the Study:
- To review current diagnostic and therapeutic best practices for bladder cancer.
- To explore emerging treatment modalities and their impact on patient outcomes.
- To highlight the importance of risk factor awareness and exposure reduction.
Main Methods:
- Comprehensive literature review of bladder cancer diagnosis and treatment.
- Analysis of various therapeutic approaches including radiation, photodynamic, gene, and chemotherapy.
- Inclusion of nanomedicine and systemic treatments for non-muscle-invasive and muscle-invasive bladder cancers.
Main Results:
- Social awareness and carcinogen reduction correlate with decreased bladder cancer mortality.
- New therapeutic agents are available for specific patient groups post-radical cystectomy.
- Established and novel treatments for both non-muscle-invasive and muscle-invasive bladder cancers are discussed.
Conclusions:
- Effective bladder cancer management requires a multi-faceted approach combining early diagnosis and advanced therapies.
- Public health initiatives targeting risk factors are crucial for reducing cancer-specific mortality.
- Continued research into novel treatments like nanomedicine is essential for improving bladder cancer patient quality of life.
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