Related Experiment Video
Updated: May 27, 2025

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
[Autoimmune thyroid disease in children and adolescents]
Sophie Stoppa-Vaucher1,2, Mirjam Dirlewanger3
1Département de pédiatrie, Réseau hospitalier neuchâtelois, 2000 Neuchâtel.
Abstract:
Autoimmune thyroid diseases, including Hashimoto's thyroiditis and Graves' disease, are the most common causes of acquired thyroid dysfunction in children and adolescents. They are often diagnosed at puberty, with a female predominance. A familial predisposition and associations with other autoimmune diseases such as celiac disease and type 1 diabetes point to underlying genetic mechanisms. This predisposition is attributed to the polymorphism of multiple HLA (Human Leukocyte Antigen) and non-HLA susceptibility genes, opening the field for the development of targeted therapies that can potentially modify the course and prognosis of autoimmune thyroid diseases.
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