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Cardiovascular Disease Risk Among Older Asian, Native Hawaiian, Pacific Islanders Lung Cancer Survivors
Yancen Pan1,2,3, Chun-Pin Esther Chang2,3, Randa Tao3,4
1Department of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, California, USA.
Cancer Medicine
|February 20, 2025
Summary
Asian, Native Hawaiian, and Pacific Islander (ANHPI) lung cancer survivors had lower risks of heart failure and ischemic heart disease than Non-Hispanic White (NHW) survivors. However, specific ANHPI subgroups faced higher risks, indicating disparities.
Area of Science:
- Oncology
- Cardiology
- Health Disparities
Background:
- Lung cancer outcomes may vary significantly among Asian, Native Hawaiian, and Pacific Islander (ANHPI) populations.
- Understanding cardiovascular disease (CVD) risk in these diverse groups post-lung cancer diagnosis is crucial.
Purpose of the Study:
- To investigate disparities in CVD risk between ANHPI and Non-Hispanic White (NHW) lung cancer survivors.
- To identify potential CVD risk factors contributing to these disparities.
Main Methods:
- Utilized the Surveillance, Epidemiology, and End Results (SEER)-Medicare registry (1999-2017).
- Analyzed data from 3920 ANHPI and 11,760 NHW lung cancer patients aged 66 years and older.
- Employed Cox proportional hazards models to assess incident CVD risk.
Main Results:
- ANHPI lung cancer patients exhibited a lower risk of heart failure (HR, 0.64) and ischemic heart disease (HR, 0.76) compared to NHW patients.
- Significant heterogeneity in heart failure risk was observed within ANHPI subgroups.
- Pacific Islander, South Asian, and Southeast Asian lung cancer patients showed an increased risk of heart failure compared to Chinese patients.
Conclusions:
- ANHPI lung cancer survivors generally face lower risks of heart failure and ischemic heart disease than NHW survivors.
- Heterogeneity exists within ANHPI subgroups regarding CVD risk.
- Further research is warranted to explore the elevated CVD risks in specific ANHPI subgroups, particularly Pacific Islanders, South Asians, and Southeast Asians.
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