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Correlation between Helicobacter pylori infection and atherosclerosis in a physical examination population and its
Lei Han1, Ruijuan Gu2, Hatira Jingsihan1
1Center of Health Management, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, China.
Insights
Helicobacter pylori (HP) infection, especially high-risk strains, is linked to increased carotid atherosclerosis (AS) in individuals undergoing physical exams. High-risk HP infection is a significant risk factor for carotid plaque formation.
Area of Science:
- Cardiovascular Medicine
- Infectious Diseases
- Public Health
Background:
- Carotid atherosclerosis (AS) is a major risk factor for stroke.
- Helicobacter pylori (HP) infection is prevalent and linked to various systemic conditions.
- The association between HP infection and AS requires further investigation in general populations.
Purpose of the Study:
- To determine the impact of Helicobacter pylori (HP) infection on carotid atherosclerosis (AS).
- To assess HP infection as a risk factor for carotid plaque (CP) formation in a physical examination cohort.
Main Methods:
- A cohort of physical examination patients was enrolled.
- Participants underwent 13C-urea breath test (13C-UBT) for HP detection and carotid ultrasound for AS assessment.
- Multivariate logistic regression analyzed risk factors for CP formation.
Main Results:
- HP-infected individuals had higher BMI, LDL-C, and uric acid levels compared to non-infected individuals.
- High-risk HP infection was associated with significant differences in age, BMI, hypertension, cholesterol, and uric acid.
- Age, smoking, systolic blood pressure, and glycosylated hemoglobin were CP risk factors between infected and non-infected groups.
Conclusions:
- Helicobacter pylori infection, particularly high-risk HP, accelerates carotid AS in the physical examination population.
- High-risk HP infection is identified as a risk factor for carotid plaque development.
Objective:
To investigate the influence of Helicobacter pylori (HP) infection on carotid atherosclerosis (AS) in the physical examination population.
Methods:
This study included physical examination patients from the First Affiliated Hospital of Xinjiang Medical University (May 2021-May 2023). Participants underwent a carbon-13 urea breath test (13C-UBT), HP antibody detection, and carotid AS assessment via colour Doppler ultrasound. The patients were divided into the HP-infected group and the non-infected group based on 13C-UBT results, with the HP-infected group further subdivided into high-risk and low-risk groups based on antibody detection. General data, laboratory indexes and carotid AS indexes were compared between the groups. Multivariate logistic regression was used to analyse carotid plaque (CP) formation risk factors.
Results:
The HP-infected group showed significantly higher body mass index levels, low-density lipoprotein cholesterol (LDL-C), and serum uric acid levels than the non-infected group (p < 0.05). The high-risk group demonstrated significant age differences, body mass index, hypertension, total cholesterol, LDL-C, and blood uric acid levels compared with the low-risk group (p < 0.05). Logistic regression identified age, smoking, systolic blood pressure and glycosylated haemoglobin as CP formation factors between the infected and non-infected groups (p < 0.05). Between the high-risk and low-risk groups, age, smoking, diabetes, systolic blood pressure and high-risk HP were identified as CP formation factors (p < 0.05).
Conclusions:
Helicobacter pylori infection, particularly high-risk HP infection, advances carotid AS in the physical examination population, with high-risk HP infection serving as a risk factor for CP formation.
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