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Related Concept Videos

Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...

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Related Experiment Video

Updated: Jun 28, 2026

Author Spotlight: Rehabilitation of Stroke Patients With a Digital Occupational Training System
07:35

Author Spotlight: Rehabilitation of Stroke Patients With a Digital Occupational Training System

Published on: December 29, 2023

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Post-stroke changes in brain structure and function can both influence acute upper limb function and subsequent

Catharina Zich1, Nick S Ward2, Nina Forss3

  • 1Department of Clinical and Movement Neuroscience, UCL Queen Square Institute of Neurology, United Kingdom; Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, United Kingdom; Medical Research Council Brain Network Dynamics Unit, University of Oxford, United Kingdom.

Neuroimage. Clinical
|February 20, 2025
PubMed
Summary
This summary is machine-generated.

Stroke recovery involves distinct brain changes for initial function versus later recovery. Understanding these differences in brain structure and function is key to developing new stroke therapies.

Keywords:
Acute strokeMEGMRIRecoverySensorimotor system

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Author Spotlight: Advancing Upper Limb Rehabilitation in Patients with Right Hemisphere Damage Using Assisted Active Exercise
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Author Spotlight: Enhancing Upper Limb Rehabilitation in Stroke Patients Through Advanced Robotic and Neuromodulation Technologies

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Related Experiment Videos

Last Updated: Jun 28, 2026

Author Spotlight: Rehabilitation of Stroke Patients With a Digital Occupational Training System
07:35

Author Spotlight: Rehabilitation of Stroke Patients With a Digital Occupational Training System

Published on: December 29, 2023

1.1K
Author Spotlight: Advancing Upper Limb Rehabilitation in Patients with Right Hemisphere Damage Using Assisted Active Exercise
04:43

Author Spotlight: Advancing Upper Limb Rehabilitation in Patients with Right Hemisphere Damage Using Assisted Active Exercise

Published on: February 9, 2024

986
Author Spotlight: Enhancing Upper Limb Rehabilitation in Stroke Patients Through Advanced Robotic and Neuromodulation Technologies
05:28

Author Spotlight: Enhancing Upper Limb Rehabilitation in Stroke Patients Through Advanced Robotic and Neuromodulation Technologies

Published on: October 11, 2024

463

Area of Science:

  • Neuroscience
  • Neurology
  • Rehabilitation Medicine

Background:

  • Stroke outcomes depend on initial impairment and recovery mechanisms.
  • Factors influencing initial stroke impairment may differ from those driving recovery.
  • Understanding brain structure and function post-stroke is crucial for improving patient outcomes.

Purpose of the Study:

  • To investigate the role of altered brain structure and function in initial upper limb motor severity and subsequent recovery post-stroke.
  • To differentiate brain changes associated with initial motor function from those related to motor recovery.
  • To identify potential therapeutic targets by analyzing the contribution of brain changes to stroke recovery.

Main Methods:

  • Utilized the Nine-Hole Peg Test to assess upper limb function in 36 stroke patients at week 1 and one month post-stroke.
  • Employed Magnetic Resonance Imaging (MRI) for brain structure analysis and Magnetoencephalography (MEG) with tactile stimulation for functional assessment.
  • Categorized patients based on high/low initial function and high/low subsequent recovery to compare brain metrics.

Main Results:

  • Lower sensorimotor beta power and greater white-matter disconnection were linked to low initial function and poor recovery.
  • Intra-hemispheric connectivity differences (structural and functional) uniquely related to initial motor function.
  • Inter-hemispheric connectivity differences (structural and functional) uniquely related to subsequent motor recovery.

Conclusions:

  • Brain structure and function changes post-stroke are related but distinct for initial impairment and recovery.
  • Identifying separate factors contributing to initial function and recovery is vital for targeted stroke rehabilitation.
  • Differentiating these processes can lead to more effective therapeutic strategies for stroke survivors.