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Related Experiment Video

Updated: May 27, 2025

Fabrication of 3D Cardiac Microtissue Arrays using Human iPSC-Derived Cardiomyocytes, Cardiac Fibroblasts, and Endothelial Cells

Fabrication of 3D Cardiac Microtissue Arrays using Human iPSC-Derived Cardiomyocytes, Cardiac Fibroblasts, and Endothelial Cells

Published on: March 14, 2021

Toward Origami-Inspired In Vitro Cardiac Tissue Models.

Antonio Sileo^1,2, Federica Montrone^1,2, Adelin Rouchon^1,2

¹Department of Surgery, University Hospital Basel, Basel 4031, Switzerland.

ACS Biomaterials Science & Engineering

|February 20, 2025

Summary

This summary is machine-generated.

Origami-folded paper scaffolds enhance cardiac tissue contraction for potential heart repair. This novel macropatterning approach improves engineered cardiac constructs for in vivo implantation.

Keywords:

Miura-ori included pattern cardiac tissue engineering cell alignment hydrogel in vitro models origami-folded paper vascular layer

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Last Updated: May 27, 2025

Fabrication of 3D Cardiac Microtissue Arrays using Human iPSC-Derived Cardiomyocytes, Cardiac Fibroblasts, and Endothelial Cells

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Published on: March 14, 2021

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Developing 3D Organized Human Cardiac Tissue within a Microfluidic Platform

Developing 3D Organized Human Cardiac Tissue within a Microfluidic Platform

Published on: June 15, 2021

Area of Science:

Biomaterials Engineering
Tissue Engineering
Regenerative Medicine

Background:

Engineered cardiac tissue patches are crucial for restoring heart function after injury.
Current methods often struggle to provide sufficient mechanical and topographical cues for optimal cardiac maturation.
Cellulose paper scaffolds offer biocompatibility and ease of modification for cardiac tissue engineering.

Purpose of the Study:

To investigate novel paper-based scaffolds for enhanced cardiac tissue engineering.
To evaluate the impact of micropatterning and macropatterning (origami folding) on cardiac construct contraction and functionality.
To demonstrate the potential for integrating microvascular networks within these constructs.

Main Methods:

Utilized customized cellulose paper scaffolds as cell culture substrates.
Investigated micropatterning to control cell orientation.
Developed macropatterns using origami folding to influence construct mechanics.
Incorporated physiologically differentiated microvascular networks.

Main Results:

Both micropatterning and origami macropatterning provided mechanical support for cardiac constructs.
Origami-folded paper scaffolds significantly enhanced mechanical contraction of the cardiac constructs.
Micropatterning alone did not substantially improve functional parameters.
Demonstrated proof of principle for combining cardiac constructs with microvascular networks.

Conclusions:

Origami-based macropatterning is essential for facilitating contraction in paper-based cardiac constructs.
This approach shows promise for developing structurally organized, contractile cardiac tissues.
The potential for creating multi-layered cardiac and vascular tissues could improve in vivo cell survival and function.