Related Experiment Video For Cancer
Updated: May 27, 2025
Detection and Monitoring of Tumor Associated Circulating DNA in Patient Biofluids
Published on: June 8, 2019
Dual-functional probe for sensitive detection of MCF-7 cells and mendelian randomization analysis of MUC1 association
Zhuzheng Wu1,2, Qingquan Chen3, Zhifeng Lin3
1Department of Health Inspection and Quarantine, School of Public Health, Fujian Medical University, Fuzhou, Fujian, China.
Abstract:
The present study successfully developed a method based on a dual-functional probe for detecting breast cancer cells MCF-7 by recognizing the MUC1 protein on the cell surface. This method integrated inductively coupled plasma mass spectrometry (ICP-MS) and fluorescence imaging technology, enhancing the sensitivity, specificity, and accuracy of breast cancer cell detection. Additionally, through two-sample Mendelian randomization (MR) analysis, we verified a potential correlation between breast cancer and MUC1 (PIVW<0.05), while also proving no potential correlation between liver cancer and MUC1 (PIVW>0.05). Furthermore, this study explored the relationship between other cancers and MUC1, indicating a potential correlation between ovarian cancer and colorectal cancer with MUC1 (PIVW<0.05). In summary, this study provides new strategies for the early diagnosis and treatment of breast cancer and offers new insights into the potential of MUC1 as a biomarker for the detection of other cancers.
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