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Published on: February 19, 2016
Structural aspects of dimeric prodrug-based carrier-free nanomedicines for tumor chemotherapy
1State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China. pliu@lzu.edu.cn.
Abstract:
The effect of flexible linker length in dimeric prodrugs was explained through their aggregation structures, as revealed by molecular dynamics simulations. The results indicated that the aggregation structure of the dimeric prodrug was controlled by the molecular structure (mainly flexible linkers) as an internal factor and the fabrication methods as an external factor.
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