Biomembrane structure at the molecular level and its application in precision medicine

Biomembranes are fundamental to our understanding of the cell, the basic building block of all life. They form important barriers between the cytoplasm and the microenvironment of the cell and separate organelles within cells. Despite substantial advances in the study of cell membrane structure models, they are still in the stage of model hypothesis due to the high complexity of the components, structures, and functions of membranes. In this review, we summarized the progresses on membrane structure, properties, and functions at the molecular level using newly developed technologies and discussed some challenges and future directions in biomembrane research from our perspective. Moreover, we demonstrated the dynamic functions of membrane proteins and their role in achieving early detection, precise diagnosis, and the development of personalized treatment strategies at the molecular level. Overall, this review aims to engage researchers in related fields and multidisciplinary readers to understand and explore biomembranes for the accurate and effective development of membrane-targeting therapeutic agents.