Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Juvenile kyphosis: an ultrastructural study.

E Ippolito, M Bellocci, A Montanaro

Journal of Pediatric Orthopedics

|May 1, 1985

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Effective optimization of irrigation networks with pressure-driven outflows at randomly selected installation nodes.

Scientific reports·2023

Same author

Lower-limb intramedullary nailing in patients with polyostotic fibrous dysplasia who had a previous unsuccessful treatment. A report of 48 cases.

Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology·2023

Same author

Pycnogenol® Supplementation Prevents Recurrent Urinary Tract Infections/Inflammation and Interstitial Cystitis.

Evidence-based complementary and alternative medicine : eCAM·2021

Same author

Author Correction: Optoelectronic mixing with high-frequency graphene transistors.

Nature communications·2021

Same author

Optoelectronic mixing with high-frequency graphene transistors.

Nature communications·2021

Same author

Photo thermal effect graphene detector featuring 105 Gbit s<sup>-1</sup> NRZ and 120 Gbit s<sup>-1</sup> PAM4 direct detection.

Nature communications·2021

Same journal

Response to "Intraoperative Duplex Ultrasonography in the Pink Pulseless Hand: A Useful Adjunct, But Not Yet a Decision-Making Standard".

Journal of pediatric orthopedics·2026

Same journal

Pediatric Nonscaphoid Carpal Fractures: Fracture Distribution and Operative Management in an Institutional Cohort and 2 National EHR Databases.

Journal of pediatric orthopedics·2026

Same journal

Osteosynthesis With Barrel-Bone Grafting Technique for Failed Recalcitrant Cases of Congenital Pseudarthrosis of Tibia: Outcomes and Complications in a Series of 17 Patients.

Journal of pediatric orthopedics·2026

Same journal

The Relationship Between Screw Placement and Southwick Angle Remodeling in Slipped Capital Femoral Epiphysis.

Journal of pediatric orthopedics·2026

Same journal

Characteristics of Hip Dysplasia in Adults With Cerebral Palsy.

Journal of pediatric orthopedics·2026

Same journal

Long-term Follow-up of Myelomeningocele Patients: Factors That Can Affect Their Walking Ability.

Journal of pediatric orthopedics·2026

See all related articles

Juvenile kyphosis is linked to abnormal cartilage in the vertebral growth plates, leading to stunted bone growth. These findings highlight potential targets for treating this spinal condition.

Area of Science:

Orthopedics
Pediatric Spine Surgery
Developmental Biology

Background:

Juvenile kyphosis is a spinal deformity affecting young individuals.
Previous research indicates potential abnormalities in spinal growth structures.

Purpose of the Study:

To investigate the histological and ultrastructural characteristics of spinal tissues in patients with juvenile kyphosis.
To identify the underlying causes of vertebral growth disturbances in this condition.

Main Methods:

Biopsy specimens from seven patients with juvenile kyphosis undergoing anterior spinal arthrodesis.
Histological, histochemical, and ultrastructural analysis of intervertebral discs, vertebral plates, growth plates, and vertebral bodies.
Assessment of cartilage matrix composition, collagen fibril structure, and mineralization patterns.

Related Experiment Videos

Main Results:

Abnormal, loose-appearing cartilage was observed in the vertebral and growth plates.
Vertebral and growth plates were absent in some vertebrae.
The cartilage matrix was rich in proteoglycans with thin collagen fibrils.
Mineralization and ossification of vertebral plates were irregular, leading to stunted vertebral bone growth.

Conclusions:

Abnormal cartilage in vertebral growth plates is a key feature of juvenile kyphosis.
These cartilaginous abnormalities disrupt normal ossification and lead to compromised vertebral bone growth.
Understanding these cellular and matrix changes is crucial for developing effective treatments for juvenile kyphosis.