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Correlation Between Blood Coagulation Profile and Viscosity: Clinical Laboratory Observational Study
Ezekiel U Nwose1, Phillip T Bwititi2
1School of Health & Medical Sciences, University of Southern Queensland, Toowoomba, QLD 4350, Australia.
Medical Sciences (Basel, Switzerland)
|February 21, 2025
Summary
Whole blood viscosity, a measure of blood stasis, shows an inverse association with hemostasis indices. This suggests estimated whole blood viscosity (eWBV) could complement traditional hemostasis tests in clinical practice.
Area of Science:
- Clinical Pathology
- Hematology
Background:
- Whole blood viscosity (WBV) is an underutilized parameter for assessing blood stasis.
- Traditional hemostasis tests (coagulation profiles) have limitations including restricted laboratory access and long turnaround times.
Purpose of the Study:
- To investigate the correlation between the index of stasis (estimated WBV) and standard indices of hemostasis.
Main Methods:
- Observational research using archived pathology data from 193 patients.
- Evaluated hemostasis indices: activated partial thromboplastin time (APTT), prothrombin time (PT), international normalization ratio (INR), and D-dimer.
- Assessed blood stasis using estimated WBV (eWBV), hematocrit, and serum protein levels.
Main Results:
- Hemostasis data were skewed, while eWBV and platelet counts were normally distributed.
- Hemostasis indices showed a significant inverse association with eWBV (p < 0.001).
- eWBV had a weak positive correlation with platelet count but a negligible negative correlation with PT and APTT.
Conclusions:
- Despite limitations, hemostasis indices are inversely associated with eWBV.
- eWBV may serve as an alternative or complementary test for evaluating hemostasis.
- Further research, potentially normalizing skewed data, is needed to enhance correlation and clinical utility.
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