Related Experiment Video

Updated: Jul 20, 2026

Early Detection of Drug-Induced Renal Hemodynamic Dysfunction Using Sonographic Technology in Rats
06:38

Early Detection of Drug-Induced Renal Hemodynamic Dysfunction Using Sonographic Technology in Rats

Published on: March 11, 2016

12.0K

Predictive ability of serum osmolarity for contrast-induced nephropathy after elective percutaneous coronary

Ahmad Samir1, Aly Radwan2, Hossam Elhossary2

  • 1Kasr AlAiny Faculty of Medicine, Cairo University, Cairo, Egypt. Ahmad.samir@kasralainy.edu.eg.

The Egyptian Heart Journal : (EHJ) : Official Bulletin of the Egyptian Society of Cardiology
|February 21, 2025
PubMed

Insights

Serum osmolarity is a practical tool to predict contrast-induced nephropathy (CIN) risk in high-risk patients undergoing procedures like percutaneous coronary intervention (PCI). Higher osmolarity, CHA2DS2VA score, and contrast volume independently predict CIN.

Area of Science:

  • Cardiology
  • Nephrology
  • Medical Imaging

Background:

  • Contrast-induced nephropathy (CIN) is a significant complication after percutaneous coronary intervention (PCI).
  • Certain patient groups face a substantially elevated risk of CIN.
  • Identifying high-risk individuals is crucial for effective prevention strategies.

Purpose of the Study:

  • To investigate serum osmolarity as a predictor of CIN in diabetic patients with heart failure undergoing coronary angiography or PCI.
  • To identify independent predictors of CIN in this high-risk cohort.

Main Methods:

  • Prospective observational analytic study of 174 eligible patients.
  • Inclusion criteria: diabetic patients with heart failure on diuretics scheduled for coronary angiography and/or PCI.
  • Data collected included baseline osmolarity, CHA2DS2VA score, and contrast volume.

Main Results:

  • CIN occurred in 24.7% of participants.
  • Patients with CIN had significantly higher baseline osmolarity.
  • Independent predictors of CIN: pre-procedure osmolarity ≥ 302.3 mOsm/L (OR 7.07), higher CHA2DS2VA score (OR 3.99), and larger contrast volume (OR 1.01).

Conclusions:

  • Serum osmolarity is a practical tool for stratifying CIN risk in high-risk patients before procedures.
  • Further research is needed to determine if targeting specific pre-procedural osmolarity thresholds can reduce post-PCI CIN.
Abstract

Keywords:
Contrast-induced nephropathy CINDehydrationDiabetes mellitusLoop diureticsOsmolarity

More Related Videos

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

5.2K
Measurement of Tissue Oxygenation Using Near-Infrared Spectroscopy in Patients Undergoing Hemodialysis04:36

Measurement of Tissue Oxygenation Using Near-Infrared Spectroscopy in Patients Undergoing Hemodialysis

Published on: October 2, 2020

2.1K

Related Concept Videos

Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration01:28

Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration

Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area. This equation is...
Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document any history...
Nephrotic Syndrome III : Nursing Management01:24

Nephrotic Syndrome III : Nursing Management

Nursing management for nephrotic syndrome adapts as the disease progresses, with strategies evolving to address advancing symptoms and complications.Early-Stage Management In the early stages, nursing interventions for nephrotic syndrome resemble those used in managing acute glomerulonephritis, focusing on symptom monitoring, fluid balance, and managing mild to moderate edema.Vital Signs: Regularly monitor blood pressure, pulse, respiratory rate, and temperature to promptly identify...
Serum Studies: Renal Function Tests01:24

Serum Studies: Renal Function Tests

Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...