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Updated: May 26, 2025
Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography
Published on: December 2, 2022
A CASE OF UVEAL MELANOMA MASQUERADING AS CHOROIDAL LYMPHOMA
Saleh Sahal H1, Stepanian Rima2, Juliano Joseph D3
1Department of Ophthalmology, Corewell Health William Beaumont Hospital Eye Institute, Royal Oak, Michigan.
Purpose:
To present a case of uveal melanoma masquerading as choroidal lymphoma.
Methods:
A retrospective case report in which medical and imaging records, including fundus photography, optical coherence tomography, fundus autofluorescence, fluorescein angiography, and ultrasonography, were reviewed.
Results:
A 77-year-old woman presenting with decreased vision was found to have a diffuse, shallow, yellow choroidal mass associated with retinal pigment epithelium pigmentary changes and exudative detachment in her right eye. Multimodal imaging demonstrated thickened choroid with a "lumpy-bumpy" appearance on optical coherence tomography, "leopard-spotting" on fundus autofluorescence, and a shallow "table-top" configuration on B scan. Systemic workup was unremarkable. The patient elected to undergo treatment with low-dose external beam radiation for presumed choroidal lymphoma. There was no response to radiation prompting retinochoroidal biopsy, which revealed spindle-cell uveal melanoma and resulted in enucleation.
Conclusion:
We present a case of uveal melanoma masquerading as choroidal lymphoma. This case highlights that uveal melanoma can rarely masquerade as other entities, including uveal lymphoma.
