Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Protein Complex Assembly02:41

Protein Complex Assembly

10.5K
Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
Many viruses self-assemble into a fully functional unit using the infected host cell to...
10.5K
Assembly of Cytoskeletal Filaments01:18

Assembly of Cytoskeletal Filaments

16.4K
Cytoskeletal filaments are polymeric forms of smaller protein subunits. However, individual cytoskeletal filaments may easily disassemble or associate with other similar filaments to form rigid structures. Microfilaments, made of actin monomers, rely on actin-binding proteins to form bundles and create networks of individual actin filaments. Microtubules rely on microtubule-associated proteins (MAPs) to form sturdy cylindrical structures. However, the proteins involved in forming complex...
16.4K
Assembly of Complex Microtubule Structures01:32

Assembly of Complex Microtubule Structures

1.8K
Complex microtubule structures are present in resting cells and in dividing cells. In resting cells, they are responsible for maintaining the cellular architecture, tracks for intracellular transport, positioning of organelles, assembly of cilia and flagella. They mediate the bipolar spindle assembly for chromosomal segregation and positioning of the cell division plate in dividing cells. The formation of microtubule complex structures depends on the cell type, cell stage, and cell function.
1.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Simultaneous optimization of assembly time and yield in programmable self-assembly.

The Journal of chemical physics·2026
Same author

Electrostatics overcome acoustic collapse to assemble, adapt, and activate levitated matter.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Fully Independent Response in Disordered Solids.

Physical review letters·2025
Same author

A computational toolbox for the assembly yield of complex and heterogeneous structures.

Nature communications·2023
Same author

Designing self-assembling kinetics with differentiable statistical physics models.

Proceedings of the National Academy of Sciences of the United States of America·2021
Same author

Self-assembly-based posttranslational protein oscillators.

Science advances·2020

Related Experiment Video

Updated: May 26, 2025

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
09:34

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Published on: February 6, 2020

7.2K

Accessing Semiaddressable Self-Assembly with Efficient Structure Enumeration.

Maximilian C Hübl1, Carl P Goodrich1

  • 1Institute of Science and Technology Austria (ISTA), Am Campus 1, 3400 Klosterneuburg, Austria.

Physical Review Letters
|February 21, 2025
PubMed
Summary
This summary is machine-generated.

Scientists developed a new algorithm for self-assembly, enabling efficient design of complex structures using reusable building blocks. This method overcomes challenges in the semi-addressable regime, improving assembly yield and scalability.

More Related Videos

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides
07:26

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides

Published on: November 21, 2013

12.8K
Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles
10:23

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Published on: May 8, 2015

11.6K

Related Experiment Videos

Last Updated: May 26, 2025

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
09:34

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Published on: February 6, 2020

7.2K
Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides
07:26

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides

Published on: November 21, 2013

12.8K
Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles
10:23

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Published on: May 8, 2015

11.6K

Area of Science:

  • Materials Science
  • Computational Chemistry
  • Nanotechnology

Background:

  • Modern self-assembly relies on building blocks with tunable interactions, but designing desired structures is challenging.
  • Current inverse design methods often use fully addressable systems (unique particles), which are not scalable.
  • Reusing building blocks (semi-addressable systems) complicates design due to off-target structures.

Purpose of the Study:

  • To develop a robust inverse design method for the semi-addressable regime.
  • To create an efficient algorithm for enumerating all possible structures from a given set of building blocks.
  • To demonstrate that economical semi-addressable designs can achieve high assembly yields.

Main Methods:

  • Developed a highly efficient algorithm to enumerate all structures formed by a set of building blocks.
  • Combined enumeration with partition-function-based calculations for yield prediction.
  • Analyzed the trade-off between building block reuse and off-target structure formation.

Main Results:

  • The enumeration algorithm efficiently identifies all possible self-assembled structures.
  • Economical semi-addressable designs were found to be feasible and effective.
  • Entropic gains from reusing blocks can outweigh off-target structures, increasing target yield.
  • The method allows for control comparable to fully addressable systems.

Conclusions:

  • A key obstacle to robust inverse design in the semi-addressable regime has been overcome.
  • Scalable and efficient self-assembly design is achievable using reusable building blocks.
  • The semi-addressable regime can offer high control and yield, rivaling fully addressable systems.