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Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
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Diamond nanoneedles for biosensing.

Mariam Quarshie1, Lena Golubewa2,3, Caterina Giraulo4

  • 1Department of Physics and Mathematics, University of Eastern Finland, Joensuu, Finland.

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|February 21, 2025
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Summary
This summary is machine-generated.

Single-crystal diamond nanoneedles (SCDNNs) show potential for medical applications. These biocompatible nanoparticles are non-cytotoxic and can be used for bioimaging and drug delivery.

Keywords:
SiV−centersbiomedical applicationsdiamond needlesphotoluminescence

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Area of Science:

  • Nanomedicine
  • Biotechnology
  • Materials Science

Background:

  • Nanoparticles and nanomaterials offer diverse medical applications, including diagnosis and therapy.
  • Understanding nano-object interactions with biological cells is crucial for realizing their full potential.

Purpose of the Study:

  • Investigate the interaction of single-crystal diamond nanoneedles (SCDNNs) with biological substances.
  • Evaluate the cellular response of human lung fibroblast cells to SCDNNs.

Main Methods:

  • Micro-photoluminescence (PL) mapping
  • Confocal microscopy
  • Lactate dehydrogenase (LDH) viability tests

Main Results:

  • SCDNNs and cells can coexist, with efficient registration of silicon vacancy (SiV-) color centers.
  • Minimal LDH release indicates non-cytotoxicity of optimally sized SCDNNs at concentrations of 2-32 µg ml-1.

Conclusions:

  • SCDNNs demonstrate potential for extra- and/or intracellular drug delivery upon surface modification.
  • Fluorescent defects in SCDNNs can be utilized for bioimaging and optical/quantum sensing.