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Cerebellar Alterations in Autism Spectrum Disorder: A Mini-Review.

Bianca Andrade Rodrigues¹, Josiane do Nascimento Silva¹, Elisa Mitiko Kawamoto^2,3

¹Laboratory of Molecular and Functional Neurobiology, Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.

Cerebellum (London, England)

|February 22, 2025

Summary

Autism spectrum disorder (ASD) involves social communication challenges and repetitive behaviors. This review highlights how cerebellum abnormalities may contribute to ASD

Keywords:

Autism spectrum disorder Cerebellar abnormalities Cerebellum

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Area of Science:

Neuroscience
Developmental Psychology

Background:

Autism spectrum disorder (ASD) is a neurodevelopmental condition affecting social communication and behavior.
Cognitive impairments are often observed in individuals with ASD.
The neurobiological underpinnings of ASD remain incompletely understood.

Purpose of the Study:

To review evidence linking cerebellar abnormalities to ASD.
To explore the role of the cerebellum in cognitive and emotional processes relevant to ASD.
To discuss implications for understanding and treating ASD.

Main Methods:

Literature review of studies on cerebellar abnormalities in ASD.
Analysis of research connecting cerebellar function to cognitive and emotional deficits in ASD.

Main Results:

Evidence suggests cerebellar alterations are implicated in the etiology of ASD.
The cerebellum's role extends beyond motor control to cognitive and emotional functions affected in ASD.

Conclusions:

Cerebellar abnormalities are a significant factor in ASD.
Understanding cerebellar involvement offers insights into ASD's complexities and potential therapeutic targets.