Related Experiment Video

Updated: May 26, 2025

Novel Sequence Discovery by Subtractive Genomics
09:40

Novel Sequence Discovery by Subtractive Genomics

Published on: January 25, 2019

8.6K

A Comprehensive Approach to Robin Sequence

Sameer Shakir1, Catharine B Garland2

  • 1Department of Plastic Surgery, Plastic and Reconstructive Surgery, Medical College of Wisconsin, 9000 West Wisconsin Avenue, Suite 340, Milwaukee, WI 53202, USA.

Clinics in Plastic Surgery
|February 22, 2025
PubMed

Insights

Robin sequence, a congenital condition causing airway obstruction, is managed by a multidisciplinary team. Treatments range from conservative measures to surgical interventions like mandibular distraction osteogenesis to avoid tracheostomy.

Area of Science:

  • Pediatric Medicine
  • Otolaryngology
  • Genetics

Background:

  • Robin sequence is a congenital condition characterized by micrognathia, glossoptosis, and airway obstruction.
  • It may occur with or without a cleft palate.
  • Effective management requires a multidisciplinary approach for complex pediatric airway issues.

Purpose of the Study:

  • To outline the multidisciplinary management strategies for Robin sequence.
  • To describe conservative and interventional treatment options.
  • To highlight the goal of avoiding tracheostomy in severe cases.

Main Methods:

  • Conservative management includes prone positioning, nasopharyngeal airways, oxygen, and feeding support.
  • Surgical interventions involve tongue-lip adhesion for anterior tongue repositioning.
  • Nonsurgical techniques like orthodontic airway plates are also utilized.
  • Mandibular distraction osteogenesis is reserved for severe cases.

Main Results:

  • Conservative measures aim to maintain a patent airway and support infant growth.
  • Surgical and nonsurgical interventions reposition the tongue to alleviate airway obstruction.
  • Mandibular distraction osteogenesis is effective in severe cases, potentially avoiding tracheostomy.

Conclusions:

  • Robin sequence necessitates a comprehensive, multidisciplinary team approach.
  • A spectrum of treatments, from conservative to surgical, is available.
  • The primary goal is to ensure airway patency and support infant development, avoiding tracheostomy when possible.

Keywords:
Cleft palateMandibular distraction osteogenesis (MDO)MicrognathiaRetrognathiaRobin sequence (RS)Tongue-based airway obstruction (TBAO)

More Related Videos

Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins11:34

Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins

Published on: August 9, 2019

6.6K
Use of Alu Element Containing Minigenes to Analyze Circular RNAs13:10

Use of Alu Element Containing Minigenes to Analyze Circular RNAs

Published on: March 10, 2020

7.3K

Related Concept Videos

RACE - Rapid Amplification of cDNA Ends02:35

RACE - Rapid Amplification of cDNA Ends

Rapid Amplification of cDNA Ends, or RACE, is one of the most effective methods to obtain a full-length cDNA from an mRNA sequence between a known internal region to the unknown sequence at the 5’ or 3’ end. The unknown region is cloned in the cDNA by a gene-specific primer that binds the known end, and a hybrid primer that attaches a predefined anchor sequence to the unknown end of the cDNA. The sequence in between is amplified by PCR with an anchor primer and a gene-specific...
6.3K
RNA-seq03:21

RNA-seq

RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while...
9.8K
Next-generation Sequencing03:00

Next-generation Sequencing

The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features....
87.0K
Maxam-Gilbert Sequencing01:05

Maxam-Gilbert Sequencing

In the same year as the discovery of the Sanger sequencing method, another group of scientists, Allan Maxam and Walter Gilbert, demonstrated their chemical-cleavage method for DNA sequencing. The Maxam-Gilbert method relies on using different chemicals that can cleave the DNA sequence at specific sites, the separation of resulting DNA fragments of variable size using electrophoresis, and deciphering the DNA sequence from the resulting gel bands.
Challenges of the Maxam-Gilbert Method
The...
10.9K
Restarting Stalled Replication Forks02:37

Restarting Stalled Replication Forks

DNA replication is initiated at sites containing predefined DNA sequences known as origins of replication. DNA is unwound at these sites by the minichromosome maintenance (MCM) helicase and other factors such as Cdc45 and the associated GINS complex.The unwound single strands are protected by replication protein A (RPA) until DNA polymerase starts synthesizing DNA at the 5’ end of the strand in the same direction as the replication fork. To prevent the replication fork from falling apart,...
5.7K