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Updated: May 26, 2025

Author Spotlight: In Vitro Investigations of Circadian Rhythms in Multicellular Systems
Published on: February 16, 2024
Circadian rhythms in stem cells and their therapeutic potential
Napasiri Putthanbut1,2, Paul Alexis Bourgade Su1,3, Jea-Young Lee1
1Center of Aging and Brain Repair, Department of Neurosurgery, University of South Florida, Tampa, USA.
Abstract:
Circadian rhythms are present in almost all cells, but their existence in stem cells has remains not well established. Circadian clock appears to be closely associated with differentiated mature cells and rarely detected in immature embryonic stem cells. Recent evidence reveals the presence of circadian genes and rhythmic physiologic activities in stem cells as well as stem cell-derived extracellular vesicle (EV) characteristics. The circadian clock entails diverse physiologic and pathological mechanisms underlying cell fate. Integration of circadian rhythm to clinical applications, such as chronotherapy, chrono-biomarker, and environment modification, may facilitate therapeutic outcomes of stem cell-based regenerative medicine. Understanding circadian rhythms in stem cells can optimize stem cell-based therapies by determining the best times for harvesting and administering stem cells, thereby enhancing therapeutic efficacy. Further research into the circadian properties of stem cells will refine stem cell-based therapies, contributing to advancements in regenerative medicine.
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