Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Oral alpha-tocopherol supplements decrease plasma gamma-tocopherol levels in humans.

G J Handelman, L J Machlin, K Fitch

    The Journal of Nutrition
    |June 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Plasma levels of tumour necrosis factor-α and adiponectin can differentiate patients with psoriatic arthritis from those with psoriasis.

    The British journal of dermatology·2019
    Same author

    Docetaxel chemotherapy in metastatic castration-resistant prostate cancer: cost of care in Medicare and commercial populations.

    Current medical research and opinion·2017
    Same author

    Conversion of S-phenylsulfonylcysteine residues to mixed disulfides at pH 4.0: utility in protein thiol blocking and in protein-S-nitrosothiol detection.

    Organic & biomolecular chemistry·2014
    Same author

    Medication use by athletes during the Athens 2004 Paralympic Games.

    British journal of sports medicine·2009
    Same author

    Newer strategies for anemia prevention in hemodialysis.

    The International journal of artificial organs·2007
    Same author

    QSYP peptide sequence is selected from phage display libraries by bovine IgG contaminants in monoclonal antibody preparations.

    BioTechniques·2003
    Same journal

    Evaluation of Energy and Nutrient Estimates from Large Language Models Using Text-Based Queries.

    The Journal of nutrition·2026
    Same journal

    Considerations for Dietary Supplements After GLP-1RA Treatment: A Narrative Review.

    The Journal of nutrition·2026
    Same journal

    The apple(juice) doesn't fall far from the tree: Children's hydration mirrors their parent's.

    The Journal of nutrition·2026
    Same journal

    Microbial-derived polyphenol metabolites and the gut microbiota: A scoping review of clinical studies.

    The Journal of nutrition·2026
    Same journal

    Hesperidin as an Emerging Nutraceutical in Modern Health and Preventive Medicine: A Narrative Review.

    The Journal of nutrition·2026
    Same journal

    Short-Chain Fatty Acids in Livestock and Aquatic Animals: Metabolic Divergence, Physiological Functions, and Product Development.

    The Journal of nutrition·2026
    See all related articles

    Elevated alpha-tocopherol intake lowers gamma-tocopherol levels in plasma. The ratio of gamma- to alpha-tocopherol is a better measure for vitamin E supplementation trials.

    Area of Science:

    • Nutritional Biochemistry
    • Human Physiology

    Background:

    • Tocopherols, a family of vitamin E compounds, play crucial roles in human health.
    • Alpha-tocopherol is the most biologically active form, but gamma-tocopherol also possesses antioxidant properties.

    Purpose of the Study:

    • To investigate the relationship between plasma alpha-tocopherol and gamma-tocopherol levels.
    • To evaluate the impact of alpha-tocopherol supplementation on other tocopherol forms in plasma.

    Main Methods:

    • Cross-sectional survey of 86 elderly individuals.
    • High-performance liquid chromatography (HPLC) for tocopherol quantification.
    • Intervention study with 8 human volunteers receiving alpha-tocopherol supplementation.

    Main Results:

    Related Experiment Videos

    • A negative correlation was observed between plasma alpha-tocopherol and gamma-tocopherol levels in elderly subjects.
    • Alpha-tocopherol supplementation in volunteers led to decreased plasma gamma- and beta-tocopherol levels.
    • Plasma gamma-tocopherol decreased to 30-50% of baseline, while alpha-tocopherol increased to 200-400%.

    Conclusions:

    • Intestinal uptake and plasma transport favor alpha-tocopherol over gamma- and beta-tocopherol.
    • The plasma gamma-tocopherol to alpha-tocopherol ratio is a suitable biomarker for monitoring alpha-tocopherol supplementation compliance.