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Persistent Corneal Epithelial Defect Following Pars Plana Vitrectomy: A Narrative Review
Makan Ziafati1, Reza Mirshahi1, Maria Vittoria Cicinelli2,3
1The Five Senses Institute, Rassoul Akram Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Seminars in Ophthalmology
|February 24, 2025
Summary
Persistent corneal epithelial defects (PCEDs) after pars plana vitrectomy (PPV) are common. Management varies from conservative to advanced therapies like topical insulin, with further research needed.
Area of Science:
- Ophthalmology
- Corneal Surgery
Background:
- Persistent corneal epithelial defects (PCEDs) following pars plana vitrectomy (PPV) pose a significant clinical challenge.
- These defects can lead to severe complications including corneal scarring and vision loss.
Purpose of the Study:
- To review the prevalence and risk factors of PCEDs after PPV.
- To summarize current management strategies for PCEDs in the context of PPV.
Main Methods:
- A systematic review of English-language studies was performed.
- Literature search conducted using PubMed and Embase databases.
Main Results:
- Prevalence of PCEDs post-PPV ranged from 0% to 78.37%.
- Risk factors include diabetes mellitus and intraoperative use of C3F8 gas.
- Management options span from bandage contact lenses to topical insulin.
Conclusions:
- PCEDs after PPV are multifactorial, requiring individualized treatment approaches.
- Advanced therapies like serum-based treatments and topical insulin show promise.
- Further prospective research is necessary to optimize treatment outcomes.
