Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Brain Imaging01:14

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Transcranial photobiomodulation improves prefrontal oxygenation and impulse control in adults with ADHD: a randomized controlled trial.

BMC psychiatry·2026
Same author

Interhemispheric Metabolic Effects of Transcranial Infrared Laser Stimulation of the Prefrontal Cortex.

Human brain mapping·2026
Same author

A qualitative study of digital CBT for veteran depression: Treatment experiences and recommendations for healthcare system integration.

Psychiatry research·2026
Same author

The longitudinal relations between physical activity, inflammation, and depression in the Health and Retirement Study.

PLOS mental health·2026
Same author

Who exhibits cognitive biases? Mapping heterogeneity in attention, interpretation, and rumination in depression.

Journal of psychopathology and clinical science·2026
Same author

Abdominal Photobiomodulation and the Gut-Brain Axis: A Systematic Review of Mechanistic and Translational Evidence.

Biomedicines·2025

Related Experiment Video

Updated: Jul 16, 2026

MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder
08:20

MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder

Published on: August 11, 2015

13.8K

Augmenting Internet-Based Cognitive Behavioral Therapy for Major Depressive Disorder With Transcranial Infrared Laser

Douglas W Barrett1, Christopher G Beevers1, F Gonzalez-Lima1

  • 1Departments of Psychology, Psychiatry and Behavioral Sciences, and Institute for Neuroscience, The University of Texas at Austin, Austin, Texas.

Biological Psychiatry Global Open Science
|February 24, 2025
PubMed
Summary

Transcranial infrared laser stimulation (TILS) enhanced internet-based cognitive behavioral therapy for depression. TILS, combined with therapy, showed a 30% greater reduction in depressive symptoms compared to therapy alone.

Keywords:
Cognitive behavioral therapyCognitive enhancementDeprexisMajor depressive disorderPrefrontal cortex stimulationTranscranial infrared laser stimulation

More Related Videos

Transcranial Direct Current Stimulation for Online Gamers
06:01

Transcranial Direct Current Stimulation for Online Gamers

Published on: November 9, 2019

7.9K
Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method
07:12

Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method

Published on: August 2, 2021

3.4K

Related Experiment Videos

Last Updated: Jul 16, 2026

MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder
08:20

MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder

Published on: August 11, 2015

13.8K
Transcranial Direct Current Stimulation for Online Gamers
06:01

Transcranial Direct Current Stimulation for Online Gamers

Published on: November 9, 2019

7.9K
Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method
07:12

Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method

Published on: August 2, 2021

3.4K

Area of Science:

  • Neuroscience
  • Psychiatry
  • Biomedical Engineering

Background:

  • Major depressive disorder is a prevalent psychiatric condition.
  • Internet-based cognitive behavioral therapy (iCBT) is an established treatment for depression.
  • Transcranial infrared laser stimulation (TILS) is a noninvasive photobiomodulation technique shown to enhance cognitive function.

Purpose of the Study:

  • To investigate the efficacy of TILS as an adjunctive therapy to iCBT for major depressive disorder.
  • To determine if TILS can augment the antidepressant effects of iCBT.

Main Methods:

  • Sixty participants with major depressive disorder received 12 weeks of iCBT (Deprexis).
  • After 2 weeks, 40 participants showing improvement were randomized to receive TILS or sham/placebo adjunct therapy.
  • Depressive symptoms were assessed using the Quick Inventory of Depressive Symptomatology-Self-Report (QIDS-SR).

Main Results:

  • The TILS group showed a 56% reduction in QIDS-SR scores, compared to 43% in the sham group.
  • TILS resulted in an additional 30% greater reduction in depressive symptoms.
  • No adverse effects were reported in the TILS group.

Conclusions:

  • TILS significantly augmented the antidepressant effects of iCBT.
  • Combining neuroenhancement techniques like TILS with cognitive interventions shows promise for improving depression treatment outcomes.
  • Further research into pairing TILS with cognitive interventions may benefit other psychiatric disorders.